Primary Cutaneous Ganglioneuroma: A Report of Two Cases and Literature ReviewWallace, Christopher A. M.D.; Hallman, James R. M.D.; Sangueza, Omar P. M.D.The American Journal of Dermatopathology: June 2003 - Volume 25 - Issue 3 - p 239-242 Extraordinary Case Reports Abstract Author Information Primary cutaneous ganglioneuroma is a rare neoplasm first described by Collins et al. in 1972. Eight cases have been reported in the English literature to date. We report two cases of solitary cutaneous ganglioneuroma, one constituting, to our knowledge, the first reported case of this entity occurring on the face. Clinically, both lesions were firm flesh-colored papules and asymptomatic, being removed primarily for cosmesis. Neither patient had any significant past medical history. Histologically, both neoplasms consisted of relatively well-circumscribed spindle cell proliferations of axons and Schwann cells with interspersed mature ganglion cells. There was also focal myxoid change. The spindle cell component stained positively for S-100 protein, and the ganglion cells stained positively for glial fibrillary acidic protein and neurofilaments by routine immunohistochemistry. From the Department of Pathology and Dermatology, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina (C.A.W., O.P.S.); and Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, District of Columbia (J.R.H.). Address correspondence and reprint requests to Omar Sangueza, M.D., Department of Pathology, Second Floor, Watlington Hall, Wake Forest University Baptist Medical Center, Winston-Salem, NC 27157. E-mail: email@example.com. © 2003 Lippincott Williams & Wilkins, Inc.