Skip Navigation LinksHome > August 2002 - Volume 24 - Issue 4 > CD117 (KIT Receptor) Expression in Merkel Cell Carcinoma
Text sizing:
A
A
A
American Journal of Dermatopathology:
Original Articles

CD117 (KIT Receptor) Expression in Merkel Cell Carcinoma

Su, Lyndon D. M.D.; Fullen, Douglas R. M.D.; Lowe, Lori M.D.; Uherova, Patricia M.D.; Schnitzer, Bertram M.D.; Valdez, Riccardo M.D.

Collapse Box

Abstract

The KIT receptor tyrosine kinase (CD117 antigen) is found in a variety of normal tissue cell types and in several malignant tumors, including acute myeloid leukemia. We recently encountered two tumors initially suspected as acute myeloid leukemia cutis and expressing CD117 that showed punctate positivity for cytokeratin 20 diagnostic for Merkel cell carcinoma. We evaluated 20 additional cases of MCC and found that 21 of 22 tumors (95%) expressed CD117. Intensity of CD117 expression did not appear to correlate with aggressive behavior. While the function of the KIT receptor in MCC is not known, its pathogenic role in other malignant neoplasms suggests the possibility of a similar role in MCC.

© 2002 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.