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American Journal of Dermatopathology:
Extraordinary Case Reviews

Skin as the Primary Site of Hodgkin's Disease:: A Case Report of Primary Cutaneous Hodgkin's Disease and Review of its Relationship With Non-Hodgkin's Lymphoma

Guitart, Joan M.D.; Fretzin, David M.D.

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We report an elderly patient who presented with a single cutaneous nodule of primary cutaneous Hodgkin's disease (PCHD). Reed-Sternberg cells, expressing CD30 and CD15, but not leukocyte common antigen (CD45RB), were identified in the neoplastic cells. Southern blot analysis failed to detect T-cell receptor or immunoglobulin gene rearrangement. A work-up for systemic disease at the time of presentation was negative, supporting the diagnosis of PCHD. Nevertheless, 1 year later, the disease course was complicated by the development of nodal HD and nonHodgkin's lymphoma (NHL). This case report supports the existence of this rare, but distinct, cutaneous tumor.

© Lippincott-Raven Publishers


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