Skip Navigation LinksHome > April 1998 - Volume 20 - Issue 2 > Skin as the Primary Site of Hodgkin's Disease:: A Case Repo...
American Journal of Dermatopathology:
Extraordinary Case Reviews

Skin as the Primary Site of Hodgkin's Disease:: A Case Report of Primary Cutaneous Hodgkin's Disease and Review of its Relationship With Non-Hodgkin's Lymphoma

Guitart, Joan M.D.; Fretzin, David M.D.

Collapse Box


We report an elderly patient who presented with a single cutaneous nodule of primary cutaneous Hodgkin's disease (PCHD). Reed-Sternberg cells, expressing CD30 and CD15, but not leukocyte common antigen (CD45RB), were identified in the neoplastic cells. Southern blot analysis failed to detect T-cell receptor or immunoglobulin gene rearrangement. A work-up for systemic disease at the time of presentation was negative, supporting the diagnosis of PCHD. Nevertheless, 1 year later, the disease course was complicated by the development of nodal HD and nonHodgkin's lymphoma (NHL). This case report supports the existence of this rare, but distinct, cutaneous tumor.

© Lippincott-Raven Publishers


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.