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Cutaneous Malakoplakia in a Patient With Acquired Immunodeficiency Syndrome (AIDS)

Barnard, Maja M.D.; Chalvardjian, Ara M.D., F.R.C.P.C.

American Journal of Dermatopathology:
Extraordinary Case Reviews

Malakoplakia is an uncommon granulomatous lesion that afflicts predominantly immunocompromised individuals but is extremely rare in acquired immunodeficiency syndrome (AIDS). We report a case of cutaneous malakoplakia in an AIDS patient that presented as a banal right axillary abscess which resolved after excision and drainage. The rarity of malakoplakia in AIDS may be due to a relative or selective preservation of antimicrobial function of monocytes. Malakoplakia is distinguished from other inflammatory or neoplastic lesions by the presence of Michaelis-Gutmann bodies. A correct diagnosis is usually made only after biopsy and is an indication to use antimicrobial agents with adequate cellular penetration and concentration.

Author Information

From the Department of Pathology, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.

Address correspondence and reprint requests to Dr. A. Chalvardjian, Department of Pathology, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8.

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