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American Journal of Dermatopathology:
Extraordinary Case Reviews

Cutaneous Malakoplakia in a Patient With Acquired Immunodeficiency Syndrome (AIDS)

Barnard, Maja M.D.; Chalvardjian, Ara M.D., F.R.C.P.C.

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Malakoplakia is an uncommon granulomatous lesion that afflicts predominantly immunocompromised individuals but is extremely rare in acquired immunodeficiency syndrome (AIDS). We report a case of cutaneous malakoplakia in an AIDS patient that presented as a banal right axillary abscess which resolved after excision and drainage. The rarity of malakoplakia in AIDS may be due to a relative or selective preservation of antimicrobial function of monocytes. Malakoplakia is distinguished from other inflammatory or neoplastic lesions by the presence of Michaelis-Gutmann bodies. A correct diagnosis is usually made only after biopsy and is an indication to use antimicrobial agents with adequate cellular penetration and concentration.

© Lippincott-Raven Publishers


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