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Cutaneous Epithelioid Angioleiomyoma

Heffernan, Michael P. M.D.; Smoller, Bruce R. M.D.; Kohler, Sabine M.D.

American Journal of Dermatopathology:
Extraordinary Case Reviews

We describe an unusual dermal neoplasm with epithelioid morphology. A 44-year-old man presented with a solitary, tender, 4-mm nodule on the leg. Excisional biopsy showed several well-circumscribed dermal epithelioid tumor nodules, prominent vascularity, and smooth muscle differentiation. We suggest the term cutaneous epithelioid angioleiomyoma for this neoplasm. In a review of the literature, we found reports of two similar cases and a recent report describing five cutaneous epithelioid leiomyosarcomas. Cutaneous epithelioid angioleiomyoma represents a rare variant of dermal smooth muscle tumor and could represent the benign counterpart to the recently described epithelioid leiomyosarcoma of the skin.

Author Information

From the Departments of Dermatology (M.P.F., B.R.S., S.K.) and Pathology (B.R.S., S.K.), Stanford University School of Medicine, Stanford, California, U.S.A.

Address correspondence to Dr. S. Kohler, Stanford University Medical Center, Laboratory of Surgical Pathology, H2110, 300 Pasteur Drive, Stanford, CA 94305, U.S.A.

© Lippincott-Raven Publishers