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Angiomatoid Melanoma: A Case of Metastatic Melanoma Mimicking a Vascular Malignancy

Adler, Michael J. M.D.; Beckstead, Jay M.D.; White, Clifton R. Jr. M.D.

American Journal of Dermatopathology:
Extraordinary Case Reports

We present a case of melanoma metastatic to forehead skin and sacral vertebra, without known primary, which, in the cutaneous metastasis, displayed striking histologic features suggesting vascular differentiation. Histopathologic examination of the lesion revealed a large, deeply extending spindle cell malignancy with numerous, cavernous, erythrocyte-filled spaces throughout and only scant melanin pigmentation, making initial diagnosis challenging. The neoplastic cells demonstrated positive staining with antibodies to S-100 protein, HMB 45, and vimentin. We suggest the term angiomatoid melanoma for this histopathologic variant.

Author Information

From the Departments of Dermatology (M.J.A.) and Pathology (J.B.), Oregon Health Sciences University, and the Dermatology Service, Department of Veterans Affairs Medical Center (C.R.W), Portland, Oregon, U.S.A.

Address correspondence and reprint requests to Dr. Clifton R. White, Jr. at Department of Dermatology, L-468, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97201, U.S.A.

© Lippincott-Raven Publishers