Skip Navigation LinksHome > October 1997 - Volume 19 - Issue 5 > Silver-Stained Nucleolar Organizer Regions in Hypertrophic a...
American Journal of Dermatopathology:

Silver-Stained Nucleolar Organizer Regions in Hypertrophic and Keloid Scars

Ghazizadeh, Mohammad M.D., Ph.D.; Miyata, Nariaki M.D.; Sasaki, Yoshihiro B.S.; Arai, Katsuyuki M.D.; Aihara, Kaoru M.D.

Collapse Box


Silver-stained nucleolar organizer regions (AgNORs) have been widely used as a marker of cellular activity and proliferation. In a retrospective study, we investigated the potential value of AgNORs in 12 hypertrophic and 24 keloid scar tissues. Ten normal skin tissues served as controls. A standard silver-staining method was used, and the mean AgNOR count of dermal fibroblastic cells in each tissue was determined. In normal skin, the mean AgNOR count of dermal fibroblasts was 1.79 ± 0.55, whereas fibroblastic cells in hypertrophic and keloid scars had mean AgNOR counts of 3.18 ± 0.56 and 5.10 ± 0.97, respectively. There was a statistically significant difference between the mean AgNOR counts of fibroblastic cells from normal skin, hypertrophic scar, and keloid scar [one-factor analysis of variance (ANOVA), p < 0.0001]. Our findings suggest that AgNOR count may be a useful marker for assessment of fibroblastic cell activity in hypertrophic and keloid scars, which may have potential value for histologic and biologic characterization of the two lesions.

© Lippincott-Raven Publishers.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.