Granular Cell DermatofibromaSoyer, H. Peter M.D.; Metze, Dieter M.D.; Kerl, Helmut M.D.American Journal of Dermatopathology: April 1997 - Volume 19 - Issue 2 - pp 168-173 Case Reports Abstract Author Information We herein describe the histopathologic findings of an otherwise stereotypical dermatofibroma replete with granular cells. The histopathologic diagnosis of dermatofibroma was underlined by immunohistochemical findings and ultrastructural examination. Cellular granularity is the result of cytoplasmic accumulation of lysosomal structures and can be observed not only in conventional granular cell tumor but in a variety of benign and malignant cutaneous neoplasms. Granular cell dermatofibroma represents a hitherto undescribed variant of dermatofibroma that can be added to the broad histopathologic spectrum of this benign fibrohistiocytic proliferation. From the Department of Dermatology, University of Graz, Graz, Austria (H.P.S., H.K.), and the Department of Dermatology, University of Muenster, Muenster, Germany (D.M.). Address correspondence to Dr. H.P. Soyer, Department of Dermatology, University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria. © Lippincott-Raven Publishers.