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Tumor Vascularity as a Prognostic Indicator in Intermediate-Thickness (0.76-4 mm) Cutaneous Melanoma: A Quantitative Assay

Rongioletti, Franco M.D.; Miracco, Clelia M.D.; Gambini, Claudio M.D.; Pastorino, Angela Biol.M.; Tosi, Pietro M.D.; Rebora, Alfredo M.D.

American Journal of Dermatopathology: October 1996 - Volume 18 - Issue 5 - pp 474-477

Tumor vascularity has been reported to be a prognostic factor in solid tumors. We studied the prognostic value of tumor vascularity in 19 primary stage I skin melanomas. Only intermediate-thickness melanomas (0.76-4.00-mm thick) were studied. They were treated surgically to provide two groups of patients. The first group of 11 patients had no evidence of metastases after a follow-up of a mean period of 72.36 months, whereas the second one developed metastases in a mean period of 46.87 months. The two groups were matched for important prognostic factors including tumor thickness, sex, and age. Vascularity was quantified by a morphometric stereological analysis on paraffin sections stained with anti CD31 monoclonal antibody. The percentage of vascular area was significantly higher in the metastasizing group than in the nonmetastasizing one. Our study suggests that increased vascularity may have a prognostic significance in intermediate-thickness melanoma.

From the Department of Dermatology (F.R., A.R.), University of Genoa, Genoa; Department of Pathology (C.M., P.T.), University of Siena, Siena; and Division of Pathology (C.G., A.P.), Galliera Hospital, Genoa, Italy.

Address correspondence and reprint requests to Franco Rongioletti, Istituto di Dermatologia, Universita' degli Studi di Genova, Viale Benedetto XV, 7, 16132 Genoa, Italy.

© Lippincott-Raven Publishers