Isolated Dyskeratotic Acanthoma A Variant of Isolated Epidermolytic Acanthoma.Roten, S. Vollenweider M.D.; Bhawan, J. M.D.American Journal of Dermatopathology: February 1995 Extraordinary Case Reports: PDF Only Abstract Disorders affecting the maturation of the epidermis are regarded as incidental findings in normal skin and otherwise unrelated benign lesions. These include epider-molytic hyperkeratosis, focal acantholytic dyskeratosis, and pagetoid dyskeratosis. The former two entities also occur as primary pathologic lesions. We report a hyper-keratotic lesion with a specific histologic pattern consisting of dyskeratotic cells throughout the epidermis and a parakeratotic horn, with large, rounded cells at all levels of the stratum corneum. Because we believe it to be a variant of the solitary, acquired lesions characterized by abnormal epidermal maturation, such as epidermolytic acanthomas, we suggest the term "dyskeratotic acanthoma" for this lesion. (C) Lippincott-Raven Publishers.