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Outcome of Adjuvant Therapy in Biliary Tract Cancers

McNamara, Mairead G. MB, PhD*; Walter, Thomas MD*,†; Horgan, Anne M. MB*,‡; Amir, Eitan MB, PhD*; Cleary, Sean MD§; McKeever, Elizabeth L.*; Min, Trisha*; Wallace, Elaine MB; Hedley, David MD, PhD*; Krzyzanowska, Monika MD*; Moore, Malcolm MD*; Gallinger, Steven MD§; Greig, Paul MD§; Serra, Stefano MD; Dawson, Laura A. MD#; Knox, Jennifer J. MD*

American Journal of Clinical Oncology:
doi: 10.1097/COC.0b013e31829e19fb
Original Articles: Gastrointestinal
Abstract

Objective: There are high rates of recurrence after definitive surgery in biliary tract cancer patients. We reviewed the use and effectiveness of adjuvant therapy (AT; chemotherapy±radiotherapy) in a single institution series.

Methods: Characteristics, treatment details, and follow-up data of all patients with biliary tract cancer who had definitive surgery from January 1987 to September 2011 were reviewed. The association between baseline variables and disease-free survival/overall survival (OS) were tested using Cox proportional hazard analysis in the univariable and multivariable settings.

Results: Analysis included 296 patients (58% male; median age, 63 y). Negative or microscopically positive resections were reported in 42% and 14%, respectively, with 44% not reported. Node positivity was reported in 35% patients. AT was given in 28% of patients with 59% receiving chemotherapy and 35% concurrent chemotherapy/radiotherapy. Disease recurred in 60% patients. AT was associated with significantly improved OS (hazard ratio, 0.41; P=0.02). Compared with R0 resection, patients with R1 resection derived significantly increased benefit from AT (P for difference 0.02). In the node positive population (n=103), AT was associated with significantly improved OS (hazard ratio, 0.60; 95% confidence interval, 0.38-0.95; P=0.03).

Conclusions: Patients with R1 resection and node positive disease receiving AT after definitive surgery seem to derive OS advantage. Large prospective trials are needed to confirm these data.

Author Information

Departments of *Medical Oncology

Palliative Care Medicine

#Radiation Oncology, Princess Margaret Hospital

Departments of §Surgery

Pathology, Toronto General Hospital, Toronto, ON, Canada

Department of Gastroenterology, Edouard Herriot Hospital, Lyon, France

Department of Medical Oncology, Waterford Regional Hospital, Waterford, Ireland

The authors declare no conflicts of interest.

Reprints: Jennifer J. Knox, MD, Department of Medical Oncology, Princess Margaret Hospital, 610 University Ave, Toronto, ON, Canada M5G 2M9. E-mail: jennifer.knox@uhn.on.ca.

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.