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Esthesioneuroblastoma of the Nasal Cavity

Hollen, Tyler R. MD*; Morris, Christopher G. MS*; Kirwan, Jessica M. MA*; Amdur, Robert J. MD*; Werning, John W. MD; Vaysberg, Mikhail DO; Mendenhall, William M. MD*

American Journal of Clinical Oncology: June 2015 - Volume 38 - Issue 3 - p 311–314
doi: 10.1097/COC.0b013e31829b5631
Original Articles: Head and Neck

Objectives: Esthesioneuroblastoma is an uncommon cancer of the nasal cavity. We describe the outcomes for 26 patients treated with curative intent with photon radiotherapy (RT) at the University of Florida.

Methods: Between May 1972 and June 2007, 26 patients received RT for previously untreated esthesioneuroblastoma of the nasal cavity. Sixteen patients were males and 10 were females with a median age of 55 years (range, 3 to 82 y). The modified Kadish stage distribution was: B, 7 patients; C, 17 patients; and D, 2 patients. Treatment modalities included the following: definitive RT, 5 patients; preoperative RT, 2 patients; and postoperative RT after resection, 19 patients. Elective neck irradiation (ENI) was performed in 17 (71%) of 24 N0 patients.

Results: Rates of local control, cause-specific survival, and absolute overall survival at 5 years were 79%, 72%, and 69%, respectively. Overall survival among patients treated with definitive RT was 20% at 5 years, compared with 81% among those who underwent surgery and adjuvant RT (P=0.01). One (6%) of 17 patients who received ENI developed a recurrence in the neck and was successfully salvaged. Ultimate neck control was 100% at 5 years for patients who received ENI versus 69% among those not receiving ENI (P=0.0173).

Conclusions: Resection combined with adjuvant RT is more effective than surgery or RT alone in the treatment of esthesioneuroblastoma. ENI reduces the risk of regional relapse in patients with Kadish stage B and C cancers.

Departments of *Radiation Oncology

Otolaryngology, University of Florida College of Medicine, Gainesville, FL

The authors declare no conflicts of interest.

Reprints: William M. Mendenhall, MD, Department of Radiation Oncology, University of Florida College of Medicine, 2000 SW Archer Rd, P.O. Box 100385, Gainesville, FL 32610-0385. E-mail: mendwm@shands.ufl.edu.

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