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Chemotherapeutic Strategies in Advanced or Metastatic Pancreatic Adenocarcinoma

Zafar, Syed F. MD; El-Rayes, Bassel F. MD

American Journal of Clinical Oncology:
doi: 10.1097/COC.0b013e318248d8bb
Review Articles

Pancreatic cancer remains a formidable challenge for oncologists. The only curative option remains surgical resection in early-staged disease. Cytotoxic chemotherapy offers a modest survival benefit in the advanced or metastatic stage. Clinical trials of therapy have not yet yielded encouraging outcomes in advanced pancreatic cancer. In this review, we highlight recent developments in therapy focusing on trials conducted in the advanced or metastatic setting and offer insight into the challenges for future studies.

Author Information

Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA

The authors declare no conflicts of interest.

Reprints: Bassel F. El-Rayes, MD, Emory University, 1365 Clifton Road NE, Atlanta, GA 30322. E-mail:

© 2014 by Lippincott Williams & Wilkins, Inc