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American Journal of Clinical Oncology:
doi: 10.1097/COC.0b013e318261084b
Original Articles: Hematopoeitic

Clinical Disparity and Favorable Prognoses for Patients With Waldeyer Ring Extranodal Nasal-type NK/T-cell Lymphoma and Diffuse Large B-cell Lymphoma

Wu, Run-Ye MD*; Li, Ye-Xiong MD*; Wang, Wei-Hu MD*; Jin, Jing MD*; Wang, Shu-Lian MD*; Liu, Yue-Ping MD*; Song, Yong-Wen MD*; Fang, Hui MD*; Ren, Hua MD*; Liu, Qing-Feng MD*; Wang, Zhao-Yang MD*; Qi, Shu-Nan MD*; Lu, Ning-Ning MD*; Chen, Bo MD*; Zhang, Xi-Mei MD*; Zhou, Li-Qiang MD; Liu, Xin-Fan MD*; Yu, Zi-Hao MD*

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Abstract

Objectives:

This study aimed to compare the clinical characteristics and prognosis of Waldeyer ring extranodal nasal-type natural killer (NK)/T-cell lymphoma (WR-NKTCL) and Waldeyer ring diffuse large B-cell lymphoma (WR-DLBCL).

Methods:

Consecutive diagnoses of 122 WR-DLBCL and 44 WR-NKTCL patients, receiving mainly primary radiotherapy in early-stage WR-NKTCL and primary chemotherapy in early-stage WR-DLBCL, were reviewed.

Results:

WR-NKTCL occurred predominately in young males, as nasopharyngeal stage I disease with B-symptoms, extranodal dissemination, and involving adjacent structures. WR-DLBCL was mainly stage II tonsillar disease with regional lymph node involvement. The 5-year overall survival (OS) and progression-free survival (PFS) rates were 74% and 67% in WR-DLBCL, respectively, and 68% (P=0.468) and 59% (P=0.303) in WR-NKTCL. In stages I and II disease, WR-DLBCL 5-year OS and PFS were 79% and 76% compared with 72% (P=0.273) and 62% (P=0.117) in WR-NKTCL. In stage I disease, WR-DLBCL 5-year OS and PFS were 81% and 81%, compared with 76% (P=0.394) and 63% (P=0.236) in WR-NKTCL. In addition, the prognostic factors and failure patterns in WR-DLBCL and WR-NKTCL differed substantially.

Conclusions:

These results indicate that remarkable clinical disparities exist between WR-DLBCL and WR-NKTCL; however, different treatment strategies for each can result in similarly favorable prognoses.

Copyright © 2012 by Lippincott Williams & Wilkins

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