Skip Navigation LinksHome > December 2009 - Volume 32 - Issue 6 > Triweekly Oxaliplatin Plus Oral Capecitabine as First-Line C...
Text sizing:
American Journal of Clinical Oncology:
doi: 10.1097/COC.0b013e3181967db3
Original Article: Gastointestinal

Triweekly Oxaliplatin Plus Oral Capecitabine as First-Line Chemotherapy in Elderly Patients With Advanced Gastric Cancer

Dong, Ningning MD*; Jiang, Wanrong MD†; Li, Huiqing PhD‡; Liu, Zhifang MD*; Xu, Xiaoqing MD†; Wang, Mingyu PhD*

Collapse Box


Objectives: To investigate the efficacy and safety of oxaliplatin plus oral capecitabine (XELOX) as first-line chemotherapy in elderly patients with advanced gastric cancer (AGC).

Patients and Methods: Forty-four previously untreated patients with AGC aged 70 or older participated in the study. They received oxaliplatin 130 mg/m2 as 2-hour intravenous infusion on day 1 and oral capecitabine 1000 mg/m2 twice daily on days 1 to 14 every 3 weeks XELOX.

Results: All patients were assessable for toxicity and 41 patients for response. Median age was 75 years (range, 70–83). In total, 215 cycles of XELOX were delivered. The response rate according to Response Evaluation Criteria in Solid Tumors was 51.2% (95% confidence interval [CI]: 35.9%–66.5%), with 2 complete responses, 19 partial responses, 11 stable diseases, and 9 progressions. At 9.5 months median follow-up, median time to progression and overall survival were 5.6 (95% CI: 4.6–6.6) and 9.8 months (95% CI: 7.4–12.2), respectively. Toxicities were generally mild. Grades 3 to 4 adverse events included: neutropenia (6 patients, 13.6%), diarrhea (6 patients, 13.6%), thrombocytopenia (5 patients, 11.4%), hand-foot syndrome (4 patients, 9.1%), nausea and vomiting (2 patients, 4.5%), and anemia (1 patient, 2.3%). Neutropenic fever occurred in 2 patients. There was no treatment-related death.

Conclusions: XELOX is active and well tolerated as first-line chemotherapy for elderly patients with AGC. Given its ease of administration, it represents a good therapeutic option in the elderly.

© 2009 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us


For additional oncology content, visit LWW Oncology Journals on Facebook.