Skip Navigation LinksHome > December 2002 - Volume 25 - Issue 6 > Hypersensitivity Reaction to Cisplatin During Chemoradiation...
American Journal of Clinical Oncology:

Hypersensitivity Reaction to Cisplatin During Chemoradiation Therapy for Gynecologic Malignancy.

Koren, Claude M.D.; Yerushalmi, Rinat M.D.; Katz, Alan M.D.; Malik, Hana R.N.; Sulkes, Aaron M.D.; Fenig, Eyal M.D.

Collapse Box


Hypersensitivity reactions to intravenous cisplatin are rare. The appearance of hypersensitivity reactions in 4 of 25 consecutive patients treated with concomitant pelvic radiation and weekly intravenous cisplatin for gynecologic malignancies is reported. The reactions appeared within hours of cisplatin delivery and included primarily fever, rash, and pruritus. Infection was ruled out by blood cultures and other laboratory studies. Affected patients were treated prophylactically with an antihistamine before subsequent courses of cisplatin, with excellent results. The high rate of hypersensitivity reactions in our series may be attributable to tumor necrosis and cytokine release caused by the pelvic irradiation. Clinicians should be aware of this potential side effect so that early premedication regimens can be instituted to prevent unnecessary toxicity.

© 2002 Lippincott Williams & Wilkins, Inc.


Article Tools


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us


For additional oncology content, visit LWW Oncology Journals on Facebook.