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CNS Listeriosis Confused With Leptomeningeal Carcinomatosis in a Patient With a Malignant Insulinoma

Mileshkin, Linda M.D.; Michael, Michael M.D.; O’Reilly, Mary M.D.; McKenzie, Allan M.D.; Stark, Richard M.D.

American Journal of Clinical Oncology: December 2002 - Volume 25 - Issue 6 - p 576-579
Article

We describe a case of presumed listeria monocytogenes rhomboencephalitis, which was initially confused with leptomeningeal carcinomatosis in a patient with a malignant carcinoid tumor. Long-term corticosteroid treatment and immunosuppression caused by malignancy predisposed the patient to developing listeriosis. The clinical and radiologic features of this illustrative case are described. Listeriosis is an important treatable differential diagnosis in patients with malignancy presenting with neurologic signs.

From the Department of Haematology and Medical Oncology (L.M., M.M., R.S.) and Department of Diagnostic Imaging (A.M.), Peter MacCallum Cancer Institute; and Department of Microbiology, St. Vincent’s Public Hospital (M.O.), Melbourne, Australia.

Address correspondence and reprint requests to Dr Linda Mileshkin, Peter MacCallum Cancer Institute, Locked Bag 1, A’Beckett Street, Victoria, Australia, 8006.

© 2002 Lippincott Williams & Wilkins, Inc.