Continuous-Infusion High-Dose Leucovorin With 5-Fluorouracil and Cisplatin for Relapsed Metastatic Breast Cancer: A Phase II Study.Booser, Daniel J. M.D.; Walters, Ronald S. M.D.; Holmes, Frankie A. M.D.; Hortobagyi, Gabriel N. M.D.American Journal of Clinical Oncology: February 2000 - Volume 23 - Issue 1 - pp 40-41 Original Article Abstract Author Information Twelve women with metastatic breast cancer were treated with continuous infusion high dose leucovorin, 5-fluorouracil and cisplatin. Toxicity was severe although the dose was lower than previously described for the treatment of other cancers, and there was little anti-tumor activity. Many other regimens are more effective and less toxic. From the Department of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, U.S.A. This study was supported in part by a grant from Immunex Corp., Seattle, WA. Address correspondence and reprint requests to Dr. Daniel J. Booser, Box 56, Breast Medical Oncology, UT M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, U.S.A. © 2000 Lippincott Williams & Wilkins, Inc.
