Reliéva, a Mahonia Aquifolium Extract for the Treatment of Adult Patients With Atopic DermatitisDonsky, Howard MD1*; Clarke, Don MD2American Journal of Therapeutics: September/October 2007 - Volume 14 - Issue 5 - pp 442-446 doi: 10.1097/MJT.0b013e31814002c1 Original Article Abstract Author Information This clinical study was conducted to determine the efficacy and safety of Reliéva cream in adult patients with atopic dermatitis (eczema). This was an open-label trial in 42 patients with atopic dermatitis treated for 12 weeks with Reliéva cream (a homeopathic product containing Psorberine, a proprietary Mahonia aquifolium extract). Efficacy and safety was assessed using Eczema Area and Severity Index scores and a Subject Reported Evaluation of Treatment. The results showed significant (P < 0.05) improvements with respect to Eczema Area and Severity Index scores by comparison to subjects' baseline scores. In addition, subjects responding to a posttreatment evaluation questionnaire indicated a substantial benefit when rating effectiveness, itching, and appearance as a result of using the study preparation. Reliéva cream appears to be a safe and effective treatment for adult patients with atopic dermatitis (eczema). 1Dermatology and Cosmetic Center of Rochester, Rochester, NY; and 2Lakeside Medical Association, Glendate, CA, and Providence Holy Cross Hospital, Mission Hills, CA. This study was supported by Apollo Pharmaceuticals, Inc., Clearwater, Florida. *Address for correspondence: Dermatology and Cosmetic Center, 1665 East Ridge Road, Rochester, NY 14621. E-mail: MDSkinCare@aol.com © 2007 Lippincott Williams & Wilkins, Inc.