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Neuroprotective Therapy in Parkinson Disease

Chen, Sheng1; Le, Weidong2*

doi: 10.1097/01.mjt.0000174353.28012.a7
Therapeutic Review

During the past decade, there has been a remarkable progress in our understanding of the biology of Parkinson disease (PD), which has been translated into searching for novel therapy for PD. Much focus is shifted from the development of drugs that only relieve PD symptoms to new generation of remedies that can potentially protect dopaminergic neurons and modify the disease course. Several novel therapeutic approaches have been tested in preclinical experiments and in clinical trials, including molecules targeting on genes involved in the pathogenesis of the disease, neurotrophic factors critical for dopaminergic neuron survival and function, new generation of dopamine receptor agonists that may possess neuroprotective effects, and agents of antioxidation, antiinflammation, and antiapoptosis. The results of these studies will shed new light to our hope that PD can be cured in the future.

1Institute of Neurology, Ruijin Hospital, Shanghai 2nd Medical University, Shanghai, China; 2Institute of Health and Sciences, Shanghai Institutes for Biological Sciences, CAS/Shanghai 2nd Medical University, P.R. China.

*Address for correspondence: Institute of Health and Sciences, Shanghai Institutes for Biological Sciences, CAS/Shanghai 2nd Medical University, P.R. China. E-mail: wdle@sibs.agcn

© 2006 Lippincott Williams & Wilkins, Inc.