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American Journal of Therapeutics:
Therapeutic Rounds: PDF Only

University of Miami Division of Clinical Pharmacology Therapeutic Rounds: Irritable Bowel Syndrome-Pathophysiology, Diagnosis, and Treatment

Schwartz, Darren; Stollman, Neil

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: Irritable bowel syndrome, or IBS, is a common disorder of the bowels that causes significant patient morbidity, work-absenteeism, physician visits, and, frequently, extensive evaluations. The syndrome has been classified as a "functional" disorder because of the lack of clearly elucidated pathophysiology, although altered visceral sensitivity, intestinal motility, and psychosocial factors all likely play a role. Treatment includes fostering a strong, trusting relationship with the patient, with pharmacotherapy directed at the predominant symptoms. The authors review the pathophysiology, diagnosis, and treatment of this difficult disorder.

(C) 2000 Lippincott Williams & Wilkins, Inc.


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