Coalescence of culturally relevant and community-based research with traditional scientific inquiry is necessary for the translation of science into practice. One methodology that has been identified as an important missing link in achieving the goal of combining science and community practice is the community-based participatory research approach, or CBPR. To demonstrate how CBPR has been successfully blended with randomized control trial (RCT) methodology, we showcase a randomized community trial that has shown efficacy in reducing cardiovascular risk factors integrating community health workers. The purpose of this article is 2-fold. First, it describes the process of merging the CBPR approach within an RCT framework and, second, it describes lessons learned in conducting CBPR-RCT research initiatives.