Skip Navigation LinksHome > April-June 2016 - Volume 30 - Issue 2 > Influence of Perceived Stress on Incident Amnestic Mild Cogn...
Text sizing:
A
A
A
Alzheimer Disease & Associated Disorders:
doi: 10.1097/WAD.0000000000000125
Original Articles

Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study

Katz, Mindy J. MPH; Derby, Carol A. PhD; Wang, Cuiling PhD; Sliwinski, Martin J. PhD; Ezzati, Ali MD; Zimmerman, Molly E. PhD; Zwerling, Jessica L. MD, MS; Lipton, Richard B. MD

Supplemental Author Material
Collapse Box

Abstract

Stress is a potentially remediable risk factor for amnestic mild cognitive impairment (aMCI). Our objective is to determine whether perceived stress predicts incident aMCI and to determine if the influence of stress on aMCI is independent of known aMCI risk factors, particularly demographic variables, depression, and apolipoprotein genotype. The Einstein Aging Study is a longitudinal community-based study of older adults. The Perceived Stress Scale (PSS) was administered annually in the Einstein Aging Study to participants (N=507; 71 developed incident aMCI; mean follow-up time=3.6 y, SD=2.0) who were aged 70 years and older, free of aMCI and dementia at baseline PSS administration, and had at least 1 subsequent annual follow-up. Cox hazard models were used to examine time to aMCI onset adjusting for covariates. High levels of perceived stress are associated with a 30% greater risk of incident aMCI (per 5-point increase in PSS: hazard ratio=1.30; 95% confidence interval, 1.08-1.58) independent of covariates. The consistency of results after covariate adjustment and the lack of evidence for reverse causation in longitudinal analyses suggest that these findings are robust. Understanding of the effect of perceived stress on cognition may lead to intervention strategies that prevent the onset of aMCI and Alzheimer dementia.

Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.