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Comparative Analysis of the Alzheimer Questionnaire (AQ) With the CDR Sum of Boxes, MoCA, and MMSE

Malek-Ahmadi, Michael MSPH; Davis, Kathryn BA; Belden, Christine M. PsyD; Sabbagh, Marwan N. MD

Alzheimer Disease & Associated Disorders: July-September 2014 - Volume 28 - Issue 3 - p 296–298
doi: 10.1097/WAD.0b013e3182769731
Brief Reports

The Alzheimer Questionnaire (AQ) has been established as a valid and accurate informant-based screening questionnaire for Alzheimer disease and amnestic mild cognitive impairment. Although the AQ’s validity and diagnostic accuracy has been established, its performance in comparison with other instruments has not. Thirty-nine amnestic mild cognitive impairment cases and 34 Alzheimer disease cases were matched on the basis of age, education, and sex to 73 cognitively normal individuals. The sample had a mean age of 82.54±7.77 years and a mean education level of 14.61±2.61 years. The diagnostic accuracy of the CDR Sum of Boxes, Mini Mental State Exam (MMSE), and Montreal Cognitive Assessment (MoCA) were compared with the AQ. The AQ correlated strongly with the CDR Sum of Boxes (r=0.79) and demonstrated similar diagnostic accuracy with the MoCA and MMSE. These results suggest that the AQ is comparable with other established informant-based and patient-based measures.

The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ

Supported by the Banner Sun Health Research Institute, NIA P30 AG 019610, ADHS AGR 2007-37, and the Arizona Alzheimer’s Research Consortium.

M.M-A.: Study concept and design, analysis and interpretation of data, and preparation of the manuscript. K.D.: Acquisition of subjects and data and preparation of the manuscript. C.M.B.: Acquisition of subjects and data and preparation of the manuscript. M.N.S.: Study concept and design, acquisition of subjects and data, and preparation of the manuscript.

The authors declare no conflicts of interest.

Reprints: Michael Malek-Ahmadi, MSPH, The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351 (e-mail: michael.ahmadi@bannerhealth.com).

Received March 30, 2012

Accepted August 3, 2012

© 2014 by Lippincott Williams & Wilkins.