Skip Navigation LinksHome > January-March 2014 - Volume 28 - Issue 1 > Clomipramine in the Treatment of Compulsive Behavior in Fron...
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Alzheimer Disease & Associated Disorders:
doi: 10.1097/WAD.0b013e318265c104
Brief Report

Clomipramine in the Treatment of Compulsive Behavior in Frontotemporal Dementia: A Case Series

Furlan, Julio C. MD, MBA, MSc, PhD*,†,‡; Henri-Bhargava, Alexandre MD,CM, FRCPC†,§; Freedman, Morris MD, FRCPC†,§,∥,¶

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Abstract

Compulsive behaviors in patients with behavioral variant frontotemporal dementia (bvFTD) occur frequently and are challenging to manage. We report three cases of probable bvFTD associated with compulsive behaviors that responded well to treatment with clomipramine at daily dosages varying from 20 to 175 mg. The titration approach involved an initial 10-mg dose that was subsequently increased in 10 mg increments on a weekly basis until symptom relief without intolerable side effects. Our case series supports the consideration for a therapeutic trial with clomipramine in bvFTD when compulsive behavior occurs in these patients. It also highlights the need for further research on pharmacological treatments in bvFTD.

Copyright © 2014 by Lippincott Williams & Wilkins

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