Skip Navigation LinksHome > July-September 2012 - Volume 26 - Issue 3 > Alpha-synuclein in the Cerebrospinal Fluid Differentiates Sy...
Alzheimer Disease & Associated Disorders:
doi: 10.1097/WAD.0b013e31823899cc
Original Articles

Alpha-synuclein in the Cerebrospinal Fluid Differentiates Synucleinopathies (Parkinson Disease, Dementia With Lewy Bodies, Multiple System Atrophy) From Alzheimer Disease

Tateno, Fuyuki MD*; Sakakibara, Ryuji MD, PhD*; Kawai, Takayuki BSci; Kishi, Masahiko MD, PhD*; Murano, Takeyoshi BSci

Collapse Box

Abstract

Background: We examined the utility of quantification of α-synuclein (SNCA) in the cerebrospinal fluid (CSF) to differentiate patients with Alzheimer disease (AD), dementia with Lewy bodies (DLB), Parkinson disease (PD), and multiple system atrophy (MSA).

Methods: Thirty-seven patients were divided into 4 age-matched and sex-matched clinical groups: AD (n=9), DLB (n=6), PD (n=11), and MSA (n=11). Eleven subjects served as neurological disease controls. The total of 48 subjects included 27 men and 21 women, aged 66.5±11.4 years. We performed a solid-phase sandwich enzyme-linked immunosorbent assay, which enables the sensitive quantification of CSF SNCA.

Results: In comparison with controls, CSF SNCA levels in AD were significantly higher (P<0.05). CSF SNCA levels in PD (P<0.001), DLB (P<0.01), and MSA (P<0.05) were all significantly lower than those in AD. However, CSF SNCA levels did not differ significantly among the 3 synucleinopathies.

Conclusions: The results of the present study suggest that quantification of CSF SNCA helps in the differentiation of synucleinopathies (PD, DLB, and MSA) from AD. However, CSF SNCA levels did not differ significantly among the 3 synucleinopathies.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.