Skip Navigation LinksHome > April 2009 - Volume 33 - Issue 4 > Immunohistochemical Studies of Trophoblastic Tumors
American Journal of Surgical Pathology:
doi: 10.1097/PAS.0b013e318191f2eb
Original Articles

Immunohistochemical Studies of Trophoblastic Tumors

Kalhor, Neda MD*; Ramirez, Pedro T. MD; Deavers, Michael T. MD*; Malpica, Anais MD*; Silva, Elvio G. MD*

Collapse Box


Although intermediate trophoblastic tumors (ITTs) are rare forms of trophoblastic neoplasia, their recognition is important as they require distinct therapeutic approaches. We have noted mixed trophoblastic tumors, with a combination of placental site trophoblastic tumor and epithelioid trophoblastic tumor patterns within the same case, and more frequently a combination of ITT with choriocarcinoma, which can create difficulty in the classification of these tumors. The distinction of the ITTs from choriocarcinoma is important because ITTs do not respond as well to chemotherapy as choriocarcinoma. In addition, ITTs can be confused with a variety of malignant neoplasms, the most common of which is poorly differentiated carcinoma of the cervix. Immunohistochemistry is one means of identifying trophoblastic tumors and of distinguishing them from other entities. We investigated the immunophenotype of 15 ITTs, 11 choriocarcinomas, and 10 primary cervical carcinomas using a panel of human placental lactogen, p63, CK5/6, CK18, human chorionic gonadotropin (hCG), human leukocyte antigen (HLAG), Mel-CAM, (CD146) carcinoembryonic antigen, CD10, inhibin, p16, and pan-keratin. CD10 was positive in all the cases of ITT and choriocarcinoma. HLA-G expression was present in 93% of ITTs and all choriocarcinoma cases. hCG was positive in 87% of ITTs and 100% of choriocarcinomas. We concluded that a panel consisting of HLA-G, CD10, and hCG can be very helpful in the identification of the ITTs. Adding CK5/6 to these markers can help to differentiate ITT from primary cervical carcinoma. However, the distinction of ITTs from choriocarcinoma cannot be accomplished on immunohistochemical studies, as they have similar immunophenotypes.

© 2009 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.