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Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC): Further Morphologic and Molecular Characterization of ESC RCC as a Distinct Entity

Trpkov, Kiril MD, FRCPC*; Abou-Ouf, Hatem PhD*; Hes, Ondřej MD, PhD; Lopez, Jose I. MD, PhD; Nesi, Gabriella MD§; Comperat, Eva MD; Sibony, Mathilde MD; Osunkoya, Adeboye O. MD#; Zhou, Ming MD, PhD**; Gokden, Neriman MD††; Leroy, Xavier MD‡‡; Berney, Daniel M. MD§§; Werneck Cunha, Isabela MD, PhD∥∥; Musto, Maria L. MD¶¶; Athanazio, Daniel A. MD##; Yilmaz, Asli MD*; Donnelly, Bryan MD***; Hyndman, Eric MD***; Gill, Anthony J. MD, PhD†††; McKenney, Jesse K. MD‡‡‡; Bismar, Tarek A. MD*

American Journal of Surgical Pathology: October 2017 - Volume 41 - Issue 10 - p 1299–1308
doi: 10.1097/PAS.0000000000000838
Original Articles

Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) has been recently described as a unique and indolent renal neoplasm, found in female patients with and without tuberous sclerosis complex. Although ESC RCC has a distinct morphology and frequent CK20 reactivity, its molecular karyotype has been previously studied only in few cases. We identified 19 ESC RCC from multiple institutions; all patients were female individuals without clinical features of tuberous sclerosis complex. Molecular karyotyping was performed in 13 cases (12 with informative result). The median age was 55 years (range: 32 to 79 y). The tumors were yellow-gray with a median size of 31 mm (range: 12 to 135 mm) and showed solid and cystic gross appearance. All tumors demonstrated typical microscopic features with solid areas admixed with variably sized macrocysts and microcysts. The cells showed eosinophilic cytoplasm with granular cytoplasmic stippling and round-to-oval nuclei. CK20 was positive in 14/19 (74%) cases. Stage pT1 was found in 17/19 (89%) patients (pT1a in 12, pT1b in 5); 1 patient each had pT2a and pT3a. A total of 15/16 patients with available follow-up were alive and without evidence of disease progression, after 1 to 169 months (median: 44 mo; mean: 49.6 mo); 3 died of other causes. The most common copy number gains were 16p13.3-16q23.1 (33% to 67%), 7p21.2-7q36.2 (42% to 50%), 13q14.2 (33%), and 19p12 (33%). The most common copy number losses included Xp11.21 (42%) and 22q11.23 (33%). Loss of heterozygosity was most frequently found at 16p11.2-11.1 (75%), Xq11.1-13.1 (75%), Xq13.1-21.1 (33%), 11p11.2-11.11 (33%), 9q21.1-22.2 (33%), and 9q33.1 (33%). ESC RCC demonstrates common molecular karyotype alterations, which further support its distinct nature.

*Calgary Laboratory Services and University of Calgary

***Division of Urology, University of Calgary, Calgary, AB, Canada

Charles University, Pilsen, Czech Republic

Cruces University Hospital, BioCruces Institute, University of the Basque Country (UPV/EHU), Barakaldo, Bizkaia, Spain

§Carregi Hospital, Florence, Italy

Pitié-Salpêtrière Hospital

Hopital Cochin, Paris

‡‡Université Lille, Lille, France

#Emory University School of Medicine, Atlanta, GA

**New York University Medical Center, New York, NY

††University of Arkansas for Medical Sciences, Little Rock, AR

§§Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

∥∥AC Camargo Cancer Center, Sao Paulo, Brazil

¶¶Diagnostico Srl Lab Pathology, Montevideo, Uruguay

##Federal University of Bahia, Faculty of Medicine of Bahia, Salvador, Brazil

†††Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia

‡‡‡Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH

Conflicts of Interest and Source of Funding: Supported in part by Calgary Laboratory Services, Southern Alberta Urology Institute, and Charles University Research Fund (project number P36), by the project CZ.1.05/2.1.00/03.0076 from the European Regional Development Fund and by the project FN 00669806. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

Correspondence: Kiril Trpkov, MD, FRCPC, Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Rockyview General Hospital, 7007 14 Street, Calgary, AB, Canada T2V 1P9 (e-mail: kiril.trpkov@cls.ab.ca).

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