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Perineural Invasion in T1 Oral Squamous Cell Carcinoma Indicates the Need for Aggressive Elective Neck Dissection

Tai, Shyh-Kuan MD, PhD*,†,‡,§; Li, Wing-Yin MD; Yang, Muh-Hwa MD, PhD†,§,¶,#; Chu, Pen-Yuan MD*; Wang, Yi-Fen MD, PhD*

American Journal of Surgical Pathology:
doi: 10.1097/PAS.0b013e318285f684
Original Articles
Abstract

Observation or elective neck dissection (END) for cN0 neck remains controversial for the treatment of T1-2 oral squamous cell carcinoma (OSCC). Perineural invasion (PNI) has been recognized as a poor prognostic factor for OSCC. However, its significance in T1 OSCC remains unclear. A detailed histologic reevaluation of PNI was carried out in 307 patients with T1-2 OSCC who received surgical treatment between June 2001 and January 2009. We found that the presence of PNI correlated with cervical lymph node metastasis in both T1 and T2 OSCC, with a lower PNI-positive rate in T1 (17.1% vs. 36.6%; P<0.001). Importantly, observation for cN0 neck was used twice as often in T1 than in T2 patients (47.4% vs. 22.8%; P<0.001). Although patients with T1 OSCC achieved significantly better outcomes, PNI correlated with neck recurrence and poor disease-specific survival (DSS) only in T1 (P<0.001 and P<0.0001) but not in T2 patients (P=0.399 and 0.1478). Of the 146 patients with T1 OSCC, PNI independently predicted cervical lymph node metastasis, neck recurrence, and poor DSS. END significantly reduced neck recurrence of T1 OSCC in PNI-positive (P=0.001) but not in PNI-negative (P=0.114) patients. In addition, END improved the 5-year DSS of T1 OSCC more in PNI-positive than in PNI-negative patients (16.2% vs. 5.4%). Our results indicate that PNI independently predicts a poor prognosis in T1 OSCC patients who are potentially curable but tend to be treated conservatively. For its efficacy in improving treatment outcomes, aggressive END is indicated for T1 OSCC patients at the presence of PNI.

Author Information

*Department of Otolaryngology

Infection and Immunity Research Center

#Institute of Clinical Medicine, National Yang-Ming University

Departments of Otolaryngology

Pathology

Medical Oncology

§Immunology Center, Taipei Veterans General Hospital, Taipei, Taiwan

Conflicts of Interest and Source of Funding: Supported by National Science Council of Taiwan (NSC 101-2314-B-010-021-MY3) and Taipei Veterans General Hospital (V99C1-117, V100C-090, V101C-057, V102C-087). The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

Correspondence: Shyh-Kuan Tai, MD, PhD, Department of Otolaryngology, Taipei Veterans General Hospital, No 201, Sec 2, ShihPai Rd, Taipei, Taiwan 11217 (e-mail: sktai@vghtpe.gov.tw).

© 2013 by Lippincott Williams & Wilkins.