Myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor are rare, slow-growing soft tissue tumors of the distal extremities with recurrent potential. Recent cytogenetic studies have shown a t(1;10)(p22;q24) or der(10)t(1;10) in combination with aberrations of chromosome 3 in a limited number of cases of both entities. Here we report a case of a 42-year-old female with a soft tissue tumor of the ankle showing hybrid morphologic features of myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor, a der(10)t(1;10), and abnormalities of chromosome 3. This hybrid lesion provides further evidence for a close relationship between these 2 tumor types.
*Department of Pathology, Brigham and Women's Hospital
‡Center for Bone and Sarcoma Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
†Departamento de Anatomía Patológica, Hospital Universitario La Paz, Universidad Autónoma, Madrid, Spain
Adrián Mariño-Enríquez is supported by a research grant from Fundación Alfonso Martín Escudero, Madrid, Spain.
Correspondence: Jason L. Hornick, MD, PhD, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115 (e-mail: firstname.lastname@example.org).
Christopher P. Elco and Adrián Mariño-Enríquez have contributed equally to this work.