Anorectal Epstein-Barr Virus Infection Mimicking Hodgkin Lymphoma in an Immunocompetent ManVasiliu, Viorel MD*; Suarez, Felipe MD†; Canioni, Danielle MD*; Hermine, Olivier MD, PhD†; Varet, Bruno MD†; Brousse, Nicole MD*American Journal of Surgical Pathology: November 2010 - Volume 34 - Issue 11 - pp 1715-1719 doi: 10.1097/PAS.0b013e3181eded23 Case Reports Abstract Author Information Anorectal Hodgkin lymphoma (HL) is rare, mainly described in human immunodeficiency virus (HIV+) patients with exceptional cases reported in immunocompetents. We report the case of a middle age HIV− male, presenting with intestinal occlusion. Rectosigmoidoscopy showed multiple anorectal nodular and ulceronecrotic masses. The biopsy specimens revealed a diffuse polymorphous inflammatory infiltrate in the lamina propria, associated with CD30+, CD20+/−, CD3-, CD15-, and ALK1- scattered large Hodgkin and/or Reed Sternberg -like cells stained by LMP1+ antibody and EBER. A diagnosis of EBV-associated atypical lymphoproliferative disease mimicking HL was made. These lesions remained stable for 2 years without treatment then disappeared leaving a mucosal scar. A later control biopsy showed a condylomatous lesion, without lymphoid lesion, suggesting a sexually acquired infection. Eight years later, the complete resolution of the lesion without any treatment is a strong argument against a malignant lymphoid process and raises doubts as to the reality of isolated anorectal HL in immunocompetent participants. Departments of *Pathology †Clinical Hematology, Necker-Enfants Malades Hospital and Paris-Descartes University, Paris, France Correspondence: Nicole Brousse, MD, Service d'Anatomie Pathologique, Hôpital Necker, 149 Rue de Sèvres drawn 75743 Paris Cedex 15 France (e-mail: email@example.com). © 2010 Lippincott Williams & Wilkins, Inc.