Skip Navigation LinksHome > August 1989 - Volume 13 - Issue 8 > Multiple Lymphomatous Polyposis of the Gastrointestinal Trac...
American Journal of Surgical Pathology:
Original Article: PDF Only

Multiple Lymphomatous Polyposis of the Gastrointestinal Tract: A Clinicopathologically Distinctive Form of Non-Hodgkin's Lymphoma of B-Cell Centrocytic Type.

O'Briain, D. S. M.B., M.R.C.Path.; Kennedy, M. J. M.B., M.R.C.P.I.; Daly, P. A. M.B., F.R.C.P.I.; O'Brien, A. A.J. M.B., M.R.C.P.I.; Tanner, W. A. M.B., F.R.C.S.I.; Rogers, P. M.Sc.; Lawlor, E. M.B., F.R.C.Path

Collapse Box

Abstract

Multiple lymphomatous polyposis of the gastrointestinal tract was initially described as mucosal lymphomatous involvement by any of a variety of Hodgkin's or non-Hodgkin's lymphomas that produced a polypoid appearance over long segments of the gastrointestinal tract. We studied four patients in whom histology revealed diffuse small cleaved cell lymphoma (one case), or intermediate lymphocytic lymphoma of diffuse type (one case), or mantle zone pattern (two cases). All four cases are classifiable as centrocytic lymphoma. Cell suspension and immunocytochemical studies demonstrated B-cells of IgMD or M type with light chain restriction (two kappa, two lambda) showing a B1 + HLA Dr + LN 2+ CD5 + CD10 +. Although all four patients had a partial response to combination chemotherapy, three of them died within 3 years. Analysis of 24 cases reported since 1971 (including the present cases) suggests that MLP is a distinct clinicopathological entity that results from gastrointestinal involvement by a B-cell centrocytic lymphoma. It is distinct from the recently described clinicopathological forms of centrocytic lymphoma and intermediate lymphocytic lymphoma, which both show extensive peripheral lymphadenopathy and splenomegaly, but it is probably closely related to them. The differences are probably attributable to distinct cell tropism or homing properties rather than to cellular histogenesis or degree of maturation.

(C) Lippincott-Raven Publishers.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.