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Neurosarcoidosis Presenting as Mononeuritis Multiplex

Mattie, Ryan MD; Irwin, Robert W. MD

American Journal of Physical Medicine & Rehabilitation: April 2014 - Volume 93 - Issue 4 - p 349–354
doi: 10.1097/PHM.0000000000000004
Case Reports

ABSTRACT Sarcoidosis is a multisystem granulomatous disease of unknown etiology, with prevalence ranging from 1 to 50 per 100,000. Neurologic involvement occurs in up to 5% of patients but can be the initial presentation of sarcoidosis in 50% of those affected by neurosarcoidosis. The authors report a case of mononeuritis multiplex of the ulnar and then the radial nerve that subsequently led to a diagnosis of sarcoidosis in a patient 8 mos after initial presentation. It is important that neurosarcoidosis be in the differential diagnosis of mononeuritis multiplex when other causes cannot be found because early treatment could help prevent progression to other nerves.

From the Division of Physical Medicine & Rehabilitation, Stanford University Department of Orthopaedic Surgery (RM); and University of Miami Leonard M. Miller School of Medicine, Florida (RWI).

All correspondence and requests for reprints should be addressed to: Robert W. Irwin, MD, University of Miami Leonard M. Miller School of Medicine, PO Box 016960 (R128), Miami, FL 33101.

Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article.

© 2014 by Lippincott Williams & Wilkins