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American Journal of Physical Medicine & Rehabilitation:
doi: 10.1097/PHM.0b013e31828cd254
Literature Review

The Beneficial Role of Intensive Exercise on Parkinson Disease Progression

Frazzitta, Giuseppe MD; Balbi, Pietro MD; Maestri, Roberto MS; Bertotti, Gabriella PT; Boveri, Natalia PT; Pezzoli, Gianni MD

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ABSTRACT: In the last decade, a considerable number of articles has shown that exercise is effective in improving motor performance in Parkinson disease. In particular, recent studies have focused on the efficacy of intensive exercise in achieving optimal results in the rehabilitation of patients with Parkinson disease. The effects of intensive exercise in promoting cell proliferation and neuronal differentiation in animal models are reported in a large cohort of studies, and these neuroplastic effects are probably related to increased expression of a variety of neurotrophic factors. The authors outline the relation between intensive exercises and neuroplastic activity on animal models of Parkinson disease and discuss the clinical results of different intensive strategies on motor performance and disease progression in patients with Parkinson disease.

© 2013 by Lippincott Williams & Wilkins


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