Skip Navigation LinksHome > October 2004 - Volume 83 - Issue 10 > Botulinum Toxin: Dosing and Dilution
American Journal of Physical Medicine & Rehabilitation:
Original Articles: Review & Analysis: Spasticity

Botulinum Toxin: Dosing and Dilution

Francisco, Gerard E. MD

Collapse Box

Abstract

Francisco GE: Botulinum toxin: Dosing and dilution. Am J Phys Med Rehabil 2004;83(suppl):S30–S37.

In the United States, the popularity of botulinum toxins as agents to treat muscle hypertonia has grown significantly over the last decade, despite lack of approval from the Food and Drug Administration for the indication of spasticity. Botox (botulinum toxin type A) and Myobloc (botulinum toxin type B) are Food and Drug Administration–approved for other indications, such as cervical dystonia. Another commercial preparation of type A, Dysport, has yet to reach the United States market as of this writing. Although botulinum toxin’s efficacy in influencing spastic hypertonia is well accepted, the impact of certain clinical issues, such as dosing and dilution, on treatment outcome is not well established by published studies. This article will review important articles and selected abstracts on the use of botulinum toxin, specifically for spastic hypertonia in adults, with emphasis on current clinical practices as they relate to dosing and dilution.

© 2004 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.