Skip Navigation LinksHome > October 2012 - Volume 112 - Issue 10 > Celiac Disease: A Medical Puzzle
AJN, American Journal of Nursing:
doi: 10.1097/01.NAJ.0000421019.77542.65
Feature Articles

Celiac Disease: A Medical Puzzle

McCabe, Mary Anne MS, RN, CCM; Toughill, Eileen H. PhD, RN, APN, CNL; Parkhill, Andrea M. BSN, RN; Bossett, Margaret Schell BSN, RN; Jevic, Melissa S. BSN, RN; Nye, Matthew L. MSN, RN-BC, OCN

Free Access
Continued Education
Podcasts
Article Outline
Collapse Box

Author Information

Mary Anne McCabe is the director of quality and accreditation for the Visiting Nurse Association (VNA) Health Group in Red Bank, NJ. Eileen H. Toughill is an associate professor of nursing at Seton Hall University in South Orange, NJ. Andrea M. Parkhill is a community health nurse, Margaret Schell Bossett is a staff nurse, and Melissa S. Jevic is a staff nurse at the VNA Health Group. Matthew L. Nye is director of client services and director of nursing at SeniorBridge Homecare, a division of Humana, in Monroe, NJ. Contact author: Eileen H. Toughill, eileen.toughill@shu.edu. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Collapse Box

Abstract

Overview: Celiac disease is a T-cell–mediated, autoimmune, genetic illness that targets the small intestine and typically resolves with removal of gluten from the diet. More widespread serologic testing indicates that celiac disease affects 0.5% to 1% of the U.S. population, but presentation is highly variable and diagnosis is often missed or delayed. Strict adherence to a gluten-free diet remains the only treatment but can be challenging. This article outlines the pathophysiology of celiac disease, discusses signs and symptoms and the four disease types, describes testing, and addresses treatment and nursing implications.

I am a registered nurse. I was treated for irritable bowel syndrome for more than 10 years. Although I was very careful with my diet, I never seemed to get better and felt sick most of the time. One day, I was admitting an elderly woman to home care and was reviewing her many diagnoses. She told me about her celiac disease and the symptoms she'd experienced. As she went down the long list, I put down my pen and looked at her. “I have the same symptoms,” I said.”

Celiac disease is a T-cell–mediated, autoimmune, genetic illness that targets the small intestine; in most people the duodenum is affected first, although often the jejunum is also involved.1 The disease has been described as “a permanent intolerance to ingested gluten that damages the small intestine, characteristically inducing crypt hyperplasia and villous atrophy, and typically resolves with removal of gluten from the diet.”2 (Gluten is a complex protein found in wheat and other grains.) Other names for the illness include celiac sprue, nontropical sprue, endemic sprue, gluten enteropathy, gluten-sensitive enteropathy, and gluten intolerance.

Although a plethora of articles have been written about this illness, many nurses and other clinicians are unaware of its prevalence and its ramifications. Celiac disease affects 0.5% to 1% of the U.S. population, according to a 2004 consensus statement by the National Institutes of Health, which also concluded that the disease “is widely underrecognized.”3 Yet clinicians are still being taught that celiac disease is a childhood illness, so that when adults present with its signs and symptoms, diagnosis is often missed or markedly delayed. The average time from onset of symptoms to diagnosis for adults in the United States is 10 years.4 The authors of this article have either personally endured or witnessed the misery of misdiagnosis. This article provides an overview of celiac disease, outlines the pathophysiology, discusses signs and symptoms and the four types of celiac disease, and addresses diagnosis and disease management. In the interest of raising nurses' awareness, we offer our own illustrative stories as well.

Back to Top | Article Outline

PREVALENCE AND RISK

Prevalence. Green and Jabri note that, although the disease was once believed to occur in only one in 3,345 people worldwide, recent studies show that actual prevalence is closer to one in 266 people worldwide,5 with many nations showing higher rates.6-8 And there are indications that prevalence is rising: for example, a retrospective Finnish study found that total prevalence among adults had doubled over two decades of study and that the increase couldn't be attributed solely to better detection.9

In Europe, celiac disease is one of the most commonly diagnosed genetic diseases.7 It has “historically been considered rare” in the United States and elsewhere,7 but more widespread use of serologic screening tests has revealed that this isn't the case. (For more on the history of how celiac disease came to be recognized, see Historical Background.10-14) In a five-year study by researchers at the University of Maryland Center for Celiac Research (UMCCR), more than 13,000 people were screened for antibodies; the researchers determined that among people with no known risk factors, the prevalence was 1:133.7 Similarly, celiac disease has long been thought to be rare in other non-European countries, but now researchers believe it has been underdiagnosed. For example, Wang and colleagues found that, of 118 Chinese children with chronic diarrhea, 14 (12%) were found to have celiac disease.15 And Bahari and colleagues found a prevalence rate of 1:114 in a convenience sample of “apparently healthy” southeastern Iranians.6

Box. Historical Back...
Box. Historical Back...
Image Tools

Risk factors. Celiac disease can manifest at any age.16 It's unclear whether incidence increases with age. A Finnish study found increased incidence among people over age 55, but the researchers were unsure whether this reflected diagnostic delay, late emergence, or both.17 Another small study concluded that the disease is indeed underdiagnosed in older adults.18 Celiac disease appears to be more prevalent in women than in men,16, 19-21 although this may reflect gender differences in health care–seeking behaviors rather than in prevalence.22, 23 In a study of 1,436 people with gluten intolerance, Bardella and colleagues found an overall female-to-male ratio of 2.3:1.24 People with autoimmune disorders may also be at higher risk for celiac disease.25

Because the disease is genetic, people with a family member who has celiac disease are at greater risk for developing the disease themselves. In the aforementioned UMCCR study, among at-risk subjects, researchers found prevalence rates of 1:22 in first-degree relatives of patients with celiac disease and 1:39 in second-degree relatives.7 In a study of 168 asymptomatic siblings of people with celiac disease, serologic screening revealed that 24% had celiac disease themselves.26 And in a concordance study of 47 sets of twins, Greco and colleagues found that in 13 of the 47 pairs identified, both twins had a clear diagnosis of celiac disease.27

I am a registered nurse. My first symptom of celiac disease appeared when I was six, when I began bruising for no apparent reason. Over time, I suffered from 26 vague and multisystem symptoms. I went from doctor to doctor and was repeatedly tested for gallbladder disease and treated for anemia, osteopenia, and other symptoms. But no one ever put the puzzle pieces together. I was finally diagnosed at the age of 63, when my brother's diagnosis of celiac disease led me to believe I had it, too; a duodenal biopsy confirmed that I did. By then, I had a hemoglobin count of 8 g/dL, was enduring frequent migraine headaches and repeated bouts of bronchitis, and was severely depressed with suicidal ideation—all of which disappeared when I eliminated gluten from my diet.”

Back to Top | Article Outline

PATHOPHYSIOLOGY

Three factors, environment, genetics, and immunology, are important to the pathogenesis of celiac disease (see Figure 1).28-30

Figure 1
Figure 1
Image Tools

Environment. Celiac disease is provoked by the ingestion of gluten, a protein found in wheat and wheat-related grains, including kamut, rye, spelt, and triticale, as well as barley.31, 32 Even tiny amounts of gluten can cause damage to the intestines; thus lifetime avoidance is essential. This can be more challenging than one might think. Gluten is also used as a stabilizer, as an emulsifier, and as a thickening agent in a wide variety of processed foods, including many common sauces and marinades, processed meats and meat substitutes, soups, and candies. Cross-contamination can also be an issue. For example, experts disagree about the safety of ingesting oats because of possible cross-contamination with wheat during the growing or processing of oats.28, 33 Many experts recommend eliminating oats from the diet as a precaution, unless the oats are specifically labeled gluten free.34-36

Genetics. In order to have celiac disease, a person must have the genetic predisposition for the disease. Although researchers have not yet identified all of the genes involved, such predisposition has been strongly linked to the genes that encode inherited human leukocyte antigen (HLA), specifically the alleles known as HLA-DQ2 and HLA-DQ8. HLAs are proteins found in most cells of the body, particularly white blood cells.31, 37 According to Fasano, 95% of patients with celiac disease express the HLA-DQ2 allele, and the remaining patients test positive for the HLA-DQ8 allele.31 However, these alleles are common, found in about one-third of the general population; having either allele is necessary but not sufficient for disease development.31, 38 Non-HLA genes are thought to play a role as well.39

Immunology. HLAs guard the body by identifying other cells as self or non-self. In people with celiac disease, the HLA-DQ2 and HLA-DQ8 alleles identify gluten as an invasive foreign body and produce antibodies (immunoglobulins) that inflame the cells of the small intestines in an attempt to protect the body. The immunoglobulins IgA and IgG are involved, particularly IgA, which is abundant in the intestines.29, 40, 41

Disease process. The immunoglobulin-induced inflammation triggers an all-out assault by the immune system in an attempt to rid the body of the foreign invader. Several mechanisms are involved. The gluten molecule is resistant to normal protein digestion by peptidases, and a long peptide chain (a toxic fraction of gliadin, which is a component of gluten) remains after digestion. In people with celiac disease, the toxic fraction gets under the epithelial cells that line the intestinal villi, triggering an immune response and inflammation.29, 36 Tissue transglutaminase (tTG), an enzyme, also appears to play a role. It's believed that tTG interacts with gliadin and converts it into a more toxic molecule, one that triggers the immune response in genetically predisposed people.5, 25, 29 The actual damage is done by cytokines, specifically interferon gamma.39, 42

Over time, chronic inflammation leads to changes in the intestines. Flattening and atrophy of the intestinal villi lead to loss of absorptive ability. The new epithelial cells produced by the crypts are unable to move up the damaged villi, leading to crypt hyperplasia and leakage of serum from the crypts.25, 39, 42

Back to Top | Article Outline

SIGNS, SYMPTOMS, AND DISEASE TYPE

Researchers have used an iceberg model in explaining celiac disease, with the smaller, visible tip representing symptomatic cases (and thus more likely to be diagnosed), while the larger, submerged portion represents asymptomatic and latent cases (less likely to be diagnosed).43, 44 Diagnosis is all the more challenging because a significant proportion of patients may present with nongastrointestinal symptoms or have no symptoms at all.3 In a health record review of 220 patients newly diagnosed with celiac disease, Balamtekin and colleagues found that 59% presented with gastrointestinal (GI) symptoms, 36% had non-GI symptoms, and 7% were asymptomatic.45 For a list of some GI and non-GI symptoms, see Signs and Symptoms of Celiac Disease.4, 41, 46-52

Box. Signs and Sympt...
Box. Signs and Sympt...
Image Tools

Presentation is highly variable; taking a thorough patient history is paramount, as more than 200 signs and symptoms have been associated with the disease.52 Symptoms may come on suddenly or gradually; and patients may present as slightly or gravely ill.53 Symptom type and severity are related to the amount of intestinal damage and individual patient response to lack of nutrients.4, 29

Types of celiac disease. According to a 2004 consensus statement on celiac disease by the National Institutes of Health, celiac disease can be classified as classical, atypical, silent, or latent.3

Classical celiac disease (also called severe) usually involves villous atrophy of much of the small intestine.3, 29 Because of the extensive intestinal damage, classical celiac disease is characterized by symptoms and sequelae of GI malabsorption, and includes symptoms such as diarrhea, abdominal pain, bloating and distension, constipation, and reflux.3, 29, 45

Atypical celiac disease may involve only the duodenum and is characterized by few or no GI symptoms; non-GI symptoms predominate.3, 19, 29 Patients who present with mild GI symptoms such as reflux and bloating may be misdiagnosed with irritable bowel syndrome. Malabsorption of a single nutrient such as calcium or iron may occur, leading to symptoms of anemia, osteopenia, or osteoporosis.5, 16, 19, 25, 45, 54 Patients may initially present with apparently unrelated symptoms, such as dental enamel defects, peripheral neuropathy, irritability, or fatigue.4, 25, 41, 55 Indeed, fatigue is a major complaint of people with celiac disease,36 and may be caused by many different factors, including malabsorption of nutrients resulting in malnutrition, anemia, a concomitant autoimmune disease, and depression.41

For both classical and atypical celiac disease, diagnosis is confirmed “by serological testing, biopsy evidence of villous atrophy, and improvement of symptoms on a gluten-free diet.”3

My wife is a registered nurse. When I was disqualified from donating blood because I was severely anemic, I was sure I had cancer. My wife convinced me to see our family doctor. Blood work revealed that what I had was not cancer but celiac disease.”

Silent celiac disease refers to cases that are asymptomatic.3 Patients learn they have celiac disease when it is detected via serologic screening or when villous atrophy is found during endoscopy or biopsy performed for other reasons.3, 29

Latent celiac disease. Patients with latent celiac disease have a positive serology but no villous atrophy on biopsy3 or negative serology that turns positive later.29

Some experts distinguish between celiac disease, wheat allergy, and gluten sensitivity.56, 57 Wheat allergy has been defined as “an adverse immunologic response to wheat proteins”; IgE antibodies play a central role.57 Gluten sensitivity has been defined as “those cases of gluten reaction in which both allergic and autoimmune mechanisms have been ruled out (diagnosis by exclusion criteria).”57 Further research is needed to clarify what some call the “spectrum of gluten disorders.”58

A closer look at two symptoms. Diarrhea associated with celiac disease may have several mechanisms.29 As prolonged inflammation destroys the epithelial barrier, the intestines become more permeable to substances usually not absorbed; they also ooze serum in a process called protein-losing enteropathy. Malabsorption of sugars and fats causes excess secretion of water in the colon, with resultant watery stool. Other undigested products, including bile salts and fatty acids, intensify the problem. Bacterial ingestion of undigested food products produces gas, causing flatulence, abdominal distention, and cramps. It's important to note that although diarrhea has long been considered the classic symptom of celiac disease, in recent years researchers have found it to be the main presenting symptom in fewer than 50% of cases.25, 59

Dermatitis herpetiformis is sometimes called celiac disease of the skin.29 Characterized as an intensely itchy, blistering rash that may be accompanied by a burning sensation, it can occur anywhere on the body. It may disappear and then recur, and is usually mirrored on both sides of the body. Some people with dermatitis herpetiformis never develop GI or malabsorptive symptoms, and many people with celiac disease never develop the rash. Fortunately, as with the other symptoms of celiac disease, dermatitis herpetiformis responds to the removal of gluten from the diet.29, 57, 60

“I am a registered nurse. My path to a diagnosis of celiac disease started at my 41st birthday party. After eating pizza and cake, I had excruciating gas and loose stool. I didn't think much of it, but over the next month these problems worsened. I visited a gastroenterologist who surmised I had irritable bowel syndrome. My symptoms steadily got worse over the next few years. It got so that I could hardly eat anything—but, of course, I was eating mostly bread products to settle my upset stomach. When I developed painful blebs on my elbows and hands, I saw a dermatologist who concluded that I'd had a reaction to something I'd touched at work and recommended wearing long-sleeved shirts and gloves. At my next visit, he concluded that I had scabies. Fed up, and with my hands still covered with blebs and often bleeding, I went to a second dermatologist, who did a punch biopsy. Two weeks later, I finally had a diagnosis: dermatitis herpetiformis secondary to celiac disease.”

Back to Top | Article Outline

TESTING FOR CELIAC DISEASE

Routine screening for celiac disease is not currently practiced in the United States.61 Some researchers support screening, especially for people in high-risk categories, such as those with first- or second-degree relatives who have celiac disease and those who have another autoimmune disease.62-64

Clinicians should consider celiac disease when a patient has multiple or vague symptoms that don't seem to fit a clear diagnosis of another illness. The presence of any of the following should prompt testing: a first- or second-degree relative with celiac disease, selective IgA deficiency, connective tissue disorders such as rheumatoid arthritis or lupus, Down syndrome, autoimmune endocrinopathies such as type 1 diabetes or Graves' disease, epilepsy, dermatitis, and chronic fatigue.41, 65 Children under the age of three years with any of the above or with failure to thrive and persistent diarrhea should also be evaluated for celiac disease.66

Testing for celiac disease currently includes serologic testing for autoantibodies, including antigliadin, tTG, deaminated gliadin peptide, and antiendomysium antibodies.67 Although the antigliadin antibodies test does not have good sensitivity, test panels include it to determine whether a person is IgA deficient. Combination testing identifies patients who are candidates for a jejunal biopsy, which remains the gold standard for diagnosis.61

Once gluten is removed from the diet, antibody levels decrease. In a longitudinal study of 20 patients, Midhagen and colleagues found that antibody titers fell sharply within one month after introduction of a gluten-free diet.68 So it's important for clinicians to teach patients that they should continue to ingest gluten until all testing is completed.

Genetic testing for the presence of the HLA genes associated with celiac disease is available. A negative result can rule out the possibility that a person will develop the disease, while a positive result indicates that, whether or not the person has symptoms, regular antibody screening should be done to determine if and when the disease becomes active.66

Back to Top | Article Outline

TREATMENT AND NURSING IMPLICATIONS

Strict adherence to a gluten-free diet remains the only treatment for people with celiac disease, and can be challenging. Fortunately, maintaining a gluten-free diet will usually reverse the trajectory of the disease, allow the intestines to heal, and cause symptoms to disappear.

Nurses can help patients to better understand both the disease and the importance of avoiding gluten. Gluten-free labeling is currently voluntary and not standardized, so “hidden” gluten is a real threat. Patients need to learn how to read labels. Ingredients lists may not list gluten directly. But if a food contains any of the glutenous grains or their derivatives (such as malt, which is made from barley), it shouldn't be consumed. Nurses, perhaps together with the team's dietician, can also teach patients how to eat a balanced diet that supplies essential nutrients while staying within a budget. For example, as they would do with any new food, patients can first buy a small amount of a gluten-free food to determine whether they like it before purchasing it in bulk. Many large supermarket chains now carry a greater variety of gluten-free foods, often at lower prices than health food stores. And most recipes can be adapted to suit a gluten-free diet without much additional expense. There has been scant research on whether people with celiac disease can benefit from vitamins and other supplements; but many people take them, and some manufacturers use wheat-based inactive ingredients in their formulations.29 Similarly, medications can also contain gluten. Nurses should teach patients to check that any vitamins, supplements, and prescription and over-the-counter drugs they take are gluten free.

Although gluten can be found in some nonfood products such as shampoos and lotions, it is not problematic unless ingested, as gluten molecules are too large to be absorbed through the skin.69, 70 But people with celiac disease should wash their hands after application to avoid hand-to-mouth exposure. Ingredient lists on lipsticks, lip balms, and oral and dental care products must be read carefully, as these products can be ingested. Manufacturers can be contacted directly for further clarification about ingredients in their products.

Many restaurants and restaurant chains are beginning to offer gluten-free choices on their menus. Nurses can encourage patients to ask about such options when eating out, and support them in doing so without embarrassment. Patients should also be taught to ask about possible cross-contamination during food preparation. For example, restaurant staff might be asked “Is gluten-free pasta cooked in water previously used to cook regular pasta?” and “Are gluten-free foods fried in oil previously used to cook foods that contain gluten?”

I am a registered nurse. I grew up in an Italian neighborhood and married a woman who only cooked Italian foods. Eliminating wheat from my diet seemed impossible. When I started reading cans, boxes, and labels, I was astounded to find wheat in just about everything—and the fact that gluten or wheat often wasn't mentioned was scary. Eating out at first was a nightmare, too. I've learned to carry gluten-free products when I travel. If an airline doesn't offer a gluten-free meal, I ask for kosher and usually find enough to eat. Now that I've found gluten-free beer and pizza, I'm a happy boy.”

Unfortunately, a small percentage of patients with celiac disease may not respond (or may stop responding) to a gluten-free diet; in such cases, the disease is called refractory celiac disease.2, 25 These patients develop complications such as diarrhea and malabsorption, and are at higher risk for ulcerative jejunitis and T-cell lymphoma. Treatment involves managing any nutritional deficiencies, possibly through total parenteral nutrition; corticosteroids or immunosuppressants may also be prescribed.

Patients need good psychosocial support as well. Because their symptoms are often vague, many patients go from provider to provider for years before receiving a diagnosis of celiac disease. (Indeed, many of us believed we were crazy because, for months and even years, no provider could find a reason for our symptoms.) Nurses can listen and provide patients with information and emotional support. They can also refer patients to knowledgeable providers who will take patients' complaints seriously, offer further information, and perform a thorough workup, including biopsy. The Celiac Sprue Association (www.csaceliacs.org) maintains a list of celiac centers that specialize in caring for patients with celiac disease, and will help patients in finding a site close to home.

I am a registered nurse. During the early 1990s, I experienced severe, unbearable itching for months with intermittent breakouts of fluid-filled bullae. I saw several physicians and was diagnosed with eczema. The third dermatologist I saw biopsied the bullae, and this revealed that I had dermatitis herpetiformis. An initial trial of prednisone just made things worse; I was then started on dapsone, with immediate improvement. The dermatologist stated that there were some indications that the only ways to stop bullae formation were to take dapsone or completely eliminate wheat from my diet; but he felt that removing wheat would be “too difficult” and that I should just take the dapsone.

I was well maintained for 13 years. But if I missed even one dose, I developed a flare-up almost immediately. In 2007, I was finally tested for celiac disease, and the results were positive. In all that time, not one provider had recommended that I go wheat free and none offered any education on the disease. I educated myself—and them. When I learned that dapsone increases the risk of cardiac problems, I went wheat free and stopped the medication. I also changed my primary provider to one who actually listens to me, although he admits to having to look up information on celiac disease and dermatitis herpetiformis.”

For some patients, especially those newly diagnosed, involvement in a support group can be helpful. Participants can help support each other in making the transition to and staying on a gluten-free diet, learn more about celiac disease, and share information on available resources. (See Resources.)

Box. Resources...
Box. Resources...
Image Tools

I am a registered nurse. One day I was standing in my office preparing to lick an envelope when a colleague who also has celiac disease entered the room and said, “You can't do that—wheat paste!” That was the moment when I really started to understand the ramifications of my new diagnosis.”

It's important that nurses encourage patients to follow up regularly with their primary care provider. People with celiac disease are at higher risk for other autoimmune diseases. Nurses should teach patients about the need for yearly serologic testing to ensure dietary adherence and assess for refractory celiac disease, periodic bone-density testing, and periodic assessment for nutritional deficiencies and possible malignancies.

Back to Top | Article Outline

MUCH MORE IS NEEDED

Since under- and misdiagnosis of celiac disease are not uncommon, we believe that further education of both health care professionals and the public is paramount. More articles in professional and lay journals are needed to raise awareness. Celiac disease should also be included in nursing and medical school curricula.

Box. A Common Tale...
Box. A Common Tale...
Image Tools

Celiac disease has not been explored widely in the nursing literature, especially in the United States. In particular, further investigation into the psychosocial aspects of celiac disease is essential. Being diagnosed with celiac disease is as life changing as being diagnosed with diabetes. One's health and one's diet—even feelings about one's self—change. Qualitative research about the lived experiences of patients with autoimmune diseases will further our understanding of the impact of such illnesses on a patient's quality of life. Quantitative research about other aspects of celiac disease is called for as well.

My mother is a registered nurse. My high school years were rather stressful for both my family and me. Although I tested above average in intelligence, I struggled to achieve passing grades. I seemed to have more trouble staying out of trouble than my friends did. When I got my driver's license, I had a terrific feeling of freedom; but after I totaled three cars, the excitement was gone. I was diagnosed with attention deficit disorder (ADD) and started on medication that helped me focus, but I still felt like I had a head full of cotton, what some have described as “brain fog.”

When I started having GI symptoms, I blamed the ADD medication; but since my dad has celiac disease, my parents decided to have me tested. My tests came back positive. Half-heartedly, I began following a gluten-free diet, but as a teenager it was hard for me to accept the restrictions. When I first started college, I continued to struggle, but sophomore year has been easier. I realize I do better and feel better on the diet. The choice and consequences are mine: go off the diet and struggle, or stay on the diet and do well. I know the difference now.”

More accurate diagnostic criteria and standardization of serologic tests are needed. This would help to support screening initiatives, thus reducing morbidity and mortality. Several comorbidities are frequently associated with celiac disease, including type 1 diabetes, cardiomyopathy, Down syndrome, peripheral neuropathy, primary biliary cirrhosis, thyroid disease, and cancer.2, 25, 71-73 In a study of 653 patients with non-Hodgkin lymphoma and 5,720 healthy controls, Catassi and colleagues concluded that celiac disease was associated with a higher risk of lymphoma, particularly gut lymphoma.74 According to the Celiac Sprue Association, undiagnosed celiac disease increases the risk of cancer by 200% to 300%.75

Studies have found significantly higher death rates in people with celiac disease compared with those without the disease. In a retrospective cohort study of more than 46,000 patients with celiac disease, celiac disease with inflammation, or latent celiac disease, all based on duodenal or jejunal biopsies, Ludvigsson and colleagues found an increased risk of mortality in all three groups.76 And in a retrospective study of 228 patients, using histologic information, Cottone and colleagues found a higher mortality rate in patients with celiac disease compared with the general population.77 Twelve deaths were observed, whereas only three were expected.

Further research is needed to determine exactly what level of gluten might be ingested without triggering an autoimmune response. Since adherence to the diet is paramount and since unintentional ingestion is possible, a better understanding of the association between even minute amounts of gluten and the disease process will help patients in their efforts to adhere. An accurate testing procedure for detecting gluten in foods and established standards for gluten-free foods in the United States are also essential. These will lay the foundation for accurate, consistent food labeling with regard to gluten. Without such labeling, people with celiac disease must often avoid foods that might actually be safe and nutritious.

Back to Top | Article Outline

REFERENCES

1. Murray J, et al. Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment Clin Gastroenterol Hepatol. 2008;6(2):186–93

2. Rostom A, et al. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease Gastroenterology. 2006;131(6):1981–2002

3. National Institutes of Health. NIH consensus statement on celiac disease. Bethesda, MD; 2004 Jun. NIH consensus and state-of-the-science statements, vol 21, no. 1; http://consensus.nih.gov/2004/2004CeliacDisease118PDF.pdf.

4. National Digestive Diseases Information Clearinghouse (NDDIC). Celiac disease. National Institute of Diabetes and Digestive and Kidney Diseases (NDDK), National Institutes of Health (NIH). 2008. http://digestive.niddk.nih.gov/ddiseases/pubs/celiac/index.aspx.

5. Green PH, Jabri B. Celiac disease Annu Rev Med. 2006;57:207–21

6. Bahari A, et al. Prevalence of celiac disease among blood donors in Sistan and Balouchestan Province, Southeastern Iran Arch Iran Med. 2010;13(4):301–5

7. Fasano A, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study Arch Intern Med. 2003;163(3):286–92

8. Tommasini A, et al. Mass screening for coeliac disease using antihuman transglutaminase antibody assay Arch Dis Child. 2004;89(6):512–5

9. Lohi S, et al. Increasing prevalence of coeliac disease over time Aliment Pharmacol Ther. 2007;26(9):1217–25

10. Guandalini S. A brief history of celiac disease Impact: a publication of the University of Chicago Celiac Disease Center. 2007;7(3):1–2 . http://www.cureceliacdisease.org/wp-content/uploads/2011/09/SU07CeliacCtr.News_.pdf.

11. Fasano A. Surprises from celiac disease Sci Am. 2009;301(2):54–61

12. Haubrich WS. Shiner of the Shiner mucosal biopsy tube Gastroenterology. 2004;127(3):740

13. McNeish AS, et al. The diagnosis of coeliac disease: a commentary on the current practices of members of the European Society for Paediatric Gastroenterology and Nutrition (ESPGAN) Arch Dis Child. 1979;54(10):783–6

14. Seah PP, et al. Antireticulin antibody: incidence and diagnostic significance Gut. 1973;14(4):311–5

15. Wang XQ, et al. Celiac disease in children with diarrhea in 4 cities in China J Pediatr Gastroenterol Nutr. 2011;53(4):368–70

16. Fernandez J, et al. Coeliac disease: clinical features in adult populations Revista Espanola de Enfermedades Digestiva. 2010;102(8):466–71

17. Vilppula A, et al. Increasing prevalence and high incidence of celiac disease in elderly people: a population-based study BMC Gastroenterol. 2009;9(49)

18. Lurie Y, et al. Celiac disease diagnosed in the elderly J Clin Gastroenterol. 2008;42(1):59–61

19. Jones S, et al. Patterns of clinical presentation of adult coeliac disease in a rural setting Nutr J. 2006;5(24)

20. Llorente-Alonso MJ, et al. Gluten intolerance: sex- and age-related features Can J Gastroenterol. 2006;20(11):719–22

21. Rashtak S, Murray J. Celiac disease in the elderly Gastroenterol Clin North Am. 2009;38(3):433–46

22. Bertakis KD, et al. Gender differences in the utilization of health care services J Fam Pract. 2000;49(2):147–52

23. Sandman D, et al. Out of touch: American men and the health care system. The Commonwealth Fund; 2000 Mar. http://www.commonwealthfund.org/Publications/Fund-Reports/2000/Mar/Out-of-Touch–American-Men-and-the-Health-Care-System.aspx.

24. Bardella MT, et al. Gluten intolerance: gender- and age-related differences in symptoms Scand J Gastroenterol. 2005;40(1):15–9

25. Green PHR, Cellier C. Celiac disease N Engl J Med. 2007;357(17):1731–43

26. Bardella MT, et al. Silent celiac disease is frequent in the siblings of newly diagnosed celiac patients Digestion. 2007;75(4):182–7

27. Greco L, et al. The first large population based twin study of coeliac disease Gut. 2002;50(5):624–8

28. Green PH, et al. Mechanisms underlying celiac disease and its neurologic manifestations Cell Mol Life Sci. 2005;62(7-8):791–9

29. Green PH, Jones R Celiac disease: a hidden epidemic. 2006 New York HarperCollins

30. Martin S. Against the grain: an overview of celiac disease J Am Acad Nurse Pract. 2008;20(5):243–50

31. Fasano A. Genetics of celiac disease. WebMD. 2012. http://emedicine.medscape.com/article/1790189-overview.

32. University of Chicago Celiac Disease Center. Treatment [fact sheet]. 2012. http://www.cureceliacdisease.org/wp-content/uploads/2011/09/CDCFactSheets6_Treatment.pdf.

33. Holm K, et al. Oats in the treatment of childhood coeliac disease: a 2-year controlled trial and a long-term clinical follow-up study Aliment Pharmacol Ther. 2006;23(10):1463–72

34. Celiac Sprue Association. Gluten-free diet: grains and flours. 2012. http://www.csaceliacs.info/grains_and_flours_glossary.jsp.

35. Mayo Clinic. Gluten-free diet: what's allowed, what's not. 2011. http://www.mayoclinic.com/health/gluten-free-diet/MY01140.

36. Presutti RJ, et al. Celiac disease Am Fam Physician. 2007;76(12):1795–802

37. Wolters VM, Wijmenga C. Genetic background of celiac disease and its clinical implications Am J Gastroenterol. 2008;103(1):190–5

38. University of Maryland Center for Celiac Research. Celiac disease FAQ. n.d. http://www.celiaccenter.org/faq.asp.

39. Briani C, et al. Celiac disease: from gluten to autoimmunity Autoimmun Rev. 2008;7(8):644–50

40. Dahlbom I, et al. Immunoglobulin G (IgG) anti-tissue transglutaminase antibodies used as markers for IgA-deficient celiac disease patients Clin Diagn Lab Immunol. 2005;12(2):254–8

41. Nelsen DA Jr.. Gluten-sensitive enteropathy (celiac disease): more common than you think Am Fam Physician. 2002;66(12):2259–66

42. Dieterich W, et al. Pathomechanisms in celiac disease Int Arch Allergy Immunol. 2003;132(2):98–108

43. Fasano A. Systemic autoimmune disorders in celiac disease Curr Opin Gastroenterol. 2006;22(6):674–9

44. Kalhan S, et al. Comparative study of histopathological Marsh grading with clinical and serological parameters in celiac iceberg of north India Indian J Pathol Microbiol. 2011;54(2):279–83

45. Balamtekin N, et al. The presentation of celiac disease in 220 Turkish children Turk J Pediatr. 2010;52(3):239–44

46. Celiac Disease Foundation. Celiac disease symptoms. n.d. http://www.celiac.org/index.php?option=com_content&view=article&id=6&Itemid=12.

47. Hadjivassiliou M, et al. Gluten ataxia Cerebellum. 2008;7(3):494–8

48. Libonati CJ Recognizing celiac disease. 2007 Fort Washington, PA Gluten Free Works Publishing

49. Ludvigsson JF, et al. Increased suicide risk in coeliac disease—a Swedish nationwide cohort study Dig Liver Dis. 2011;43(8):616–22

50. Malterre T. Digestive and nutritional considerations in celiac disease: could supplementation help? Altern Med Rev. 2009;14(3):247–57

51. Mayo Clinic. Celiac disease symptoms. 2011. http://www.mayoclinic.com/health/celiac-disease/DS00319/DSECTION=symptoms.

52. University of Chicago Celiac Disease Center. Symptoms [fact sheet]. 2012. http://www.cureceliacdisease.org/wp-content/uploads/2011/09/CDCFactSheets2_Symptoms.pdf.

53. Falchuk ZM. The hows and whys of celiac disease Celiac Sprue Association Lifeline. 1999;17(2):1–4 . http://www.csaceliacs.info/hows_and_whys.jsp.

54. Green PH, Jabri B. Coeliac disease Lancet. 2003;362(9381):383–91

55. Barker J, Liu E. Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditions Adv Pediatr. 2008;55:349–65

56. Pietzak M. Celiac disease, wheat allergy, and gluten sensitivity: when gluten free is not a fad J Parenter Enteral Nutr. 2012;36(1 Suppl):68S–75S

57. Sapone A, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification BMC Med. 2012;10(13)

58. University of Maryland Center for Celiac Research. University of Maryland School of Medicine researchers identify key pathogenic differences between celiac disease and gluten sensitivity. [press release]. 2011 Mar 10. http://somvweb.som.umaryland.edu/absolutenm/templates/?a=1474&z=5.

59. Rampertab SD, et al. Trends in the presentation of celiac disease Am J Med. 2006;119(4):355.e9–355.e14

60. Hadjivassiliou M, et al. Gluten sensitivity: from gut to brain Lancet Neurol. 2010;9(3):318–30

61. National Digestive Diseases Information Clearinghouse (NDDIC). Testing for celiac disease. National Institute of Diabetes and Digestive and Kidney Diseases (NDDK), National Institutes of Health (NIH). 2009. http://digestive.niddk.nih.gov/ddiseases/pubs/celiactesting.

62. Ch’ng CL, et al. Celiac disease and autoimmune thyroid disease Clin Med Res. 2007;5(3):184–92

63. Fasano A. European and North American populations should be screened for coeliac disease Gut. 2003;52(2):168–9

64. Shamir R, et al. Cost-effectiveness analysis of screening for celiac disease in the adult population Med Decis Making. 2006;26(3):282–93

65. Michael M. Recognizing and managing celiac disease in primary care J Am Acad Nurse Pract. 2003;15(3):108–14

66. University of Chicago Celiac Disease Center. Genetic testing [fact sheet]. 2012. http://www.cureceliacdisease.org/wp-content/uploads/2011/09/CDCFactSheets4_Genetic.pdf.

67. Anderson RP. Coeliac disease: current approach and future prospects Intern Med J. 2008;38(10):790–9

68. Midhagen G, et al. Antibody levels in adult patients with coeliac disease during gluten-free diet: a rapid initial decrease of clinical importance J Intern Med. 2004;256(6):519–24

69. Celiac Sprue Association. Label reading 101. 2012. http://www.csaceliacs.info/label_reading_101.jsp.

70. Mayo Clinic. Celiac disease: can gluten be absorbed through the skin? 2012. http://www.mayoclinic.com/health/celiac-disease/AN01623.

71. Chin RL, Latov N. Peripheral neuropathy and celiac disease Curr Treat Options Neurol. 2005;7(1):43–8

72. Frustaci A, et al. Celiac disease associated with autoimmune myocarditis Circulation. 2002;105(22):2611–8

73. University of Chicago Center for Peripheral Neuropathy. Types of peripheral neuropathy–inflammatory. Celiac disease. 2012. http://peripheralneuropathycenter.uchicago.edu/learnaboutpn/typesofpn/inflammatory/celiac.shtml.

74. Catassi C, et al. Risk of non-Hodgkin lymphoma in celiac disease JAMA. 2002;287(11):1413–9

75. Celiac Sprue Association. Celiac disease facts. 2010. http://www.csaceliacs.info/celiacdiseasefacts.jsp.

76. Ludvigsson J, et al. Symptoms and signs in individuals with serology positive for celiac disease but normal mucosa BMC Gastroenterol. 2009;9(57)

77. Cottone M, et al. Mortality and causes of death in celiac disease in a Mediterranean area Dig Dis Sci. 1999;44(12):2538–41

For more than 32 additional continuing nursing education articles on gastrointestinal topics, go to www.nursingcenter.com/ce.

Keywords:

celiac disease; celiac sprue; gluten; gluten intolerance; gluten-sensitive enteropathy

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.