Rare, Serious Skin Reactions From AcetaminophenAschenbrenner, Diane S. MS, RNAJN The American Journal of Nursing: December 2013 - Volume 113 - Issue 12 - p 22,23 doi: 10.1097/01.NAJ.0000438863.44907.60 Drug Watch Abstract Author Information Acetaminophen use can, in very rare instances, produce serious, life-threatening skin infections, such as Stevens–Johnson Syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis. These skin reactions can occur anytime with the use of acetaminophen, even if the drug has been used safely in the past. Diane S. Aschenbrenner recently retired as course coordinator for undergraduate pharmacology at Johns Hopkins University School of Nursing in Baltimore, MD. She also coordinates Drug Watch: firstname.lastname@example.org. © 2013 Lippincott Williams & Wilkins. All rights reserved.