* The FDA has reported cases of children unintentionally exposed to estradiol transdermal spray (Evamist) who then exhibited signs of premature puberty and gynecomastia.
* Pets exposed to the spray may also be in danger.
* Women using Evamist, which is sprayed on the inner forearm, should be advised not to allow children or pets to come in contact with that arm.
Diane S. Aschenbrenner is the course coordinator for undergraduate pharmacology at Johns Hopkins University School of Nursing in Baltimore, MD. She also coordinates Drug Watch: email@example.com.