Skip Navigation LinksHome > March 2010 - Volume 110 - Issue 3 > Drug Interaction Decreases Clopidogrel's Effectiveness
AJN, American Journal of Nursing:
doi: 10.1097/01.NAJ.0000368957.03506.0f
Drug Watch

Drug Interaction Decreases Clopidogrel's Effectiveness

Aschenbrenner, Diane S. MS, APRN, BC

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* The labeling for clopidogrel (Plavix) has been revised to indicate that when the drug is taken together with the proton pump inhibitor omeprazole, a drug interaction may occur that can decrease clopidogrel's therapeutic effectiveness.

* Patients requiring drug therapy to decrease gastric acidity while taking clopidogrel should take either an H2-antagonist (excepting cimetidine) or an antacid.

© 2010 Lippincott Williams & Wilkins. All rights reserved.


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