At Children's Hospital Boston, the cardiovascular operating room nurses led an initiative aimed at reducing surgical site infections (SSIs) in pediatric patients undergoing cardiac surgery. After first standardizing how skin preparation was performed, the nurses sought to determine which agents might be most effective. A literature review yielded relevant research; a survey of other pediatric surgery centers was also conducted. Based on what they learned, the nurses were able to recommend, implement, and evaluate a practice change. This has resulted in reduced SSI rates and improved patient outcomes.