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Detection of HIV-1 RNA in seminal plasma samples from treated patients with undetectable HIV-1 RNA in blood plasma

Marcelin, Anne-Genevièvea,b; Tubiana, Rolandc,d; Lambert-Niclot, Sidoniea,b; Lefebvre, Gillese; Dominguez, Stéphaniec,d; Bonmarchand, Manuelaf; Vauthier-Brouzes, Danielee; Marguet, Françoisec,d; Mousset-Simeon, Nathalieg; Peytavin, Gillesh; Poirot, Catherineg,i

doi: 10.1097/QAD.0b013e32830abdc8
Research Letters

Five percent of 145 HIV-1 infected men enrolled in an assisted reproductive technology (ART) program harbored detectable HIV-1 RNA in semen, although they had no other sexually transmitted disease and their blood viral load was undetectable for at least 6 months under antiretroviral treatment. This result justifies measuring HIV-1 RNA in semen before the ART process and suggests that a residual risk of transmission has to be mentioned to the patients who would like to have unprotected sexual intercourse.

aUPMC Univ Paris 06, EA 2387, France

bAP-HP, Hôpital Pitié Salpêtrière, Laboratoire de Virologie, France

cAP-HP, Hôpital Pitié Salpêtrière, Service de Maladies Infectieuses, France

dINSERM U720, France

eAP-HP, Hôpital Pitié Salpêtrière, Service de Gynécologie-Obstétrique, France

fAP-HP, Hôpital Pitié Salpêtrière, Service de Médecine Interne, France

gAP-HP, Hôpital Pitié Salpêtrière, Unité de Biologie de la Reproduction, France

hAP-HP, Hôpital Bichat-Claude Bernard, Service de Pharmacie, France

iUPMC Univ Paris 06, EA 1533, Paris, France.

Correspondence to Anne-Geneviève Marcelin, PharmD, PhD, Department of Virology, 83 boulevard de l'hôpital, 75013 Paris, France. Tel: +33 1 42177401; fax: +33 1 42177411; e-mail: anne-genevieve.marcelin@psl.aphp.fr

© 2008 Lippincott Williams & Wilkins, Inc.