AIDS

Skip Navigation LinksHome > November 2007 - Volume 21 - Issue 17 > Positive outcomes of HAART at 24 months in HIV-infected pati...
AIDS:
doi: 10.1097/QAD.0b013e32828cc8b7
Clinical Science

Positive outcomes of HAART at 24 months in HIV-infected patients in Cambodia

Ferradini, Laurenta,b; Laureillard, Didierb,c; Prak, Naromd; Ngeth, Chanchhayad; Fernandez, Marcelob; Pinoges, Loretxua; Puertas, Gloriaa; Taburet, Anne-Mariee; Ly, Naryf; Rouzioux, Christineg; Balkan, Sunab; Quillet, Catherineb; Delfraissy, Jean-Françoish,i

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Abstract

Objectives: African and Asian cohort studies have demonstrated the feasibility and efficacy of HAART in resource-poor settings. The long-term virological outcome and clinico-immunological criteria of success remain important questions. We report the outcomes at 24 months of antiretroviral therapy (ART) in patients treated in a Médecins Sans Frontières/Ministry of Health programme in Cambodia.

Methods: Adults who started HAART 24 ± 2 months ago were included. Plasma HIV-RNA levels were assessed by real-time polymerase chain reaction. Factors associated with virological failure were analysed using logistic regression.

Results: Of 416 patients, 59.2% were men; the median age was 33.6 years. At baseline, 95.2% were ART naive, 48.9% were at WHO stage IV, and 41.6% had a body mass index less than 18 kg/m2. The median CD4 cell count was 11 cells/μl. A stavudine–lamivudine–efavirenz-containing regimen was initiated predominantly (81.0%). At follow-up (median 23.8 months), 350 (84.1%) were still on HAART, 53 (12.7%) had died, six (1.4%) were transferred, and seven (1.7%) were lost to follow-up. Estimates of survival were 85.5% at 24 months. Of 346 tested patients, 259 (74.1%) had CD4 cell counts greater than 200 cells/μl and 306 (88.4%) had viral loads of less than 400 copies/ml. Factors associated with virological failure at 24 months were non-antiretroviral naive, an insufficient CD4 cell gain of less than 350 cells/μl or a low trough plasma ART concentration. In an intention-to-treat analysis, 73.6% of patients were successfully treated.

Conclusion: Positive results after 2 years of advanced HIV further demonstrate the efficacy of HAART in the medium term in resource-limited settings.

© 2007 Lippincott Williams & Wilkins, Inc.

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