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Unexpected drug–drug interaction between tipranavir/ritonavir and enfuvirtide

de Requena, Daniel González; Calcagno, Andrea; Bonora, Stefano; Ladetto, Laura; D'Avolio, Antonio; Sciandra, Mauro; Siccardi, Marco; Bargiacchi, Olivia; Sinicco, Alessandro; Di Perri, Giovanni

doi: 10.1097/01.aids.0000247121.19951.fa
Research Letters

Fifty-five patients placed on tipranavir/ritonavir 500/200 mg twice a day (27 with enfuvirtide and 28 without) underwent tipranavir and ritonavir plasma concentration measurements by high-pressure liquid chromatography. Markedly higher tipranavir and ritonavir trough concentrations were observed in enfuvirtide recipients. The modelling of sparse plasma samples using a first order absorption and elimination monocompartmental model without time lag predicted higher tipranavir elimination half-life and volume of distribution in enfuvirtide takers. This unexpected drug–drug interaction warrants further investigation.

Department of Infectious Diseases, University of Turin, Turin, Italy.

Received 14 June, 2006

Accepted 29 June, 2006

© 2006 Lippincott Williams & Wilkins, Inc.