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AIDS:
doi: 10.1097/01.aids.0000247121.19951.fa
Research Letters

Unexpected drug–drug interaction between tipranavir/ritonavir and enfuvirtide

de Requena, Daniel González; Calcagno, Andrea; Bonora, Stefano; Ladetto, Laura; D'Avolio, Antonio; Sciandra, Mauro; Siccardi, Marco; Bargiacchi, Olivia; Sinicco, Alessandro; Di Perri, Giovanni

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Abstract

Fifty-five patients placed on tipranavir/ritonavir 500/200 mg twice a day (27 with enfuvirtide and 28 without) underwent tipranavir and ritonavir plasma concentration measurements by high-pressure liquid chromatography. Markedly higher tipranavir and ritonavir trough concentrations were observed in enfuvirtide recipients. The modelling of sparse plasma samples using a first order absorption and elimination monocompartmental model without time lag predicted higher tipranavir elimination half-life and volume of distribution in enfuvirtide takers. This unexpected drug–drug interaction warrants further investigation.

© 2006 Lippincott Williams & Wilkins, Inc.

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