Decreased pregnancy rate after in-vitro fertilization in HIV-infected women receiving HAART

Coll, Oriola,b; Suy, Annaa,b; Figueras, Francescb; Vernaeve, Valériea; Martínez, Estebanb; Mataró, Daniela; Durban, Mercèa; Lonca, Montserratb; Vidal, Ricarda,b; Gatell, José Maríab

Research Letters

A study on in-vitro fertilization (IVF) was conducted among HIV-infected women. In these patients, a reduced pregnancy rate after IVF was observed if the patient's own oocytes were used. However, no significant reduction in the pregnancy rate was found if donated oocytes were used. The CD4 lymphocyte count was independently associated with ovarian resistance to hyperstimulation. Subclinical hypogonadism mediated by immunosuppression may explain these observations, suggesting the need to optimize the immunological status of the patient before considering assisted reproduction treatments.

aClinica Eugin

bHospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain.

Received 16 May, 2005

Revised 17 June, 2005

Accepted 24 June, 2005

© 2006 Lippincott Williams & Wilkins, Inc.