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Prevention of vertical HIV transmission: additive protective effect of elective Cesarean section and zidovudine prophylaxis

Kind, Christian1,10; Rudin, Christoph2; Siegrist, Claire-Anne3; Wyler, Claire-Anne3; Biedermann, Kurt4; Lauper, Urs5; Irion, Olivier6; Schüpbach, Jörg7; Nadal, David8; Swiss Neonatal HIV Study Group

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1Division of Neonatology, Kantonsspital, St Gallen, Switzerland

2University Children's Hospital, Basel, Switzerland

3University Children's Hospital, Genève, Switzerland

4Womens Hospital, Chur, Switzerland

5University Women's Hospital, Zurich, Switzerland

6University Women's Hospital, Genève, Switzerland

7National Centre for Retroviruses, University of Zürich, Switzerland

8Infectious Disease Unit, University Children's Hospital, Zürich, Switzerland.

9See Appendix for principal collaborators.

10Requests for reprints to: Dr C. Kind, Division of Neonatology, Frauenklinik, Kantonsspital, Rorschacherstrasse 75, CH-9007 St Gallen, Switzerland.

Sponsorship: Financial support provided by the Swiss Federal Office of Public Health.

Date of receipt: 8 July 1997; revised: 6 September 1997; accepted: 10 October 1997.

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Objective: To study the effect of elective Cesarean section and zidovudine prophylaxis on vertical HIV transmission.

Design: Prospective study.

Setting: Obstetric and paediatric clinics in Switzerland.

Participants: Children of mothers with HIV infection identified before or at delivery.

Interventions: Routine use of elective Cesarean section for HIV-infected parturients by some Swiss centres since 1985. National recommendation for zidovudine prophylaxis in mid-1994.

Main outcome measure: HIV infection status of children.

Results: In a cohort of 494 children born at least 6 months before the analysis date, 67 out of 414 children with known infection status were found to be infected, giving an overall transmission rate of 16.2% [95% confidence interval (CI), 13.0–18.5]. Elective Cesarean section with intact membranes and without previous labour was associated with a lower transmission rate of 6% [odds ratio (OR), 0.29; 95% CI, 0.12–0.70; P = 0.006 versus other delivery modes]. Transmission rate was intermediate after spontaneous delivery or non-elective Cesarean section (18%), and higher after obstetric interventions (27%; test for trend, P < 0.001). Since mid-1994, 78% of all women with registered pregnancies have received some form of zidovudine prophylaxis. Transmission rate was reduced from 17 to 7% after any zidovudine exposure (OR, 0.4; 95% CI, 0.11–1.41). Combined use of elective Cesarean section and zidovudine resulted in a 0% transmission rate (none out of 31), compared with 8% (seven out of 86) after elective Cesarean section without zidovudine, 17% (four out of 24) after zidovudine alone, and 20% (55 out of 271) after no intervention.

Conclusions: Elective Cesarean section and zidovudine prophylaxis appear to have an additive effect in the prevention of vertical HIV transmission.

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Many factors have been investigated for their potential role in the prevention of mother-to-child transmission of HIV. Cesarean section has been associated with a reduced transmission rate in some prospective cohort studies [1,2], but not in others [3]. Since 1985, some centres in Switzerland have observed a policy of routinely offering HIV-positive pregnant women an elective Cesarean section by 38 weeks of pregnancy, whereas others have not. The Swiss prospective cohort study of children born to HIV-infected mothers has previously reported a marked reduction in transmission rate after elective Cesarean section, defined as an abdominal delivery performed before onset of labour and with intact membranes [4].

In 1994, the AIDS Clinical Trials Group (ACTG) 076 trial [5] demonstrated that the combined prenatal, intrapartum and postnatal use of zidovudine (ZDV) reduced the rate of mother-to-child transmission of HIV from 25.5 to 8.3%. This led to the recommendation of ZDV prophylaxis in HIV-infected pregnant women in many countries, including Switzerland. The present study reports on the effect of ZDV use in the presence or absence of elective Cesarean section in the Swiss prospective cohort study of children born to HIV-infected mothers.

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Since 1986, children of mothers known to be HIV-infected at delivery were enrolled in a prospective study encompassing the whole of Switzerland [6]. For the present study, follow-up data on all children born before 1 July 1996 were analysed. Follow-up until determination of infection status, but at least for 6 months, was required. In twins, the data of only one member of a pair, randomly chosen, were used.

Before the beginning of the study some obstetric centres had already chosen a policy of routinely offering HIV-positive pregnant women an elective Cesarean section by 38 weeks of pregnancy, whereas others did not. Both categories of centres participated equally in the national study. In mid-1994 a national recommendation for ZDV use for the prevention of vertical HIV transmission was issued and accepted by all study participants.

Children were classified as infected if they had detectable HIV antibodies beyond 24 months of life or positive virus detection tests in at least two blood samples by at least two different methods (antigen after heat-mediated disruption of immune complexes [7,8], polymerase chain reaction, virus culture). For classification as uninfected, the absence of HIV-related symptoms and either no detectable HIV antibodies beyond 15 months or negative virus detection tests in at least two samples after the age of 1 month by at least two different methods were required. All other children were classified as indeterminate.

Potential risk factors for vertical transmission ascertained at birth were as follows: maternal age, parity, gravidity (not distinguishing between spontaneous and induced abortions), injecting drug use, health status (HIV-associated systemic symptoms corresponding to class IV according to the 1986 Centers for Disease Control and Prevention classification system) [9], use of ZDV during pregnancy and intrapartum, sex of infant, gestational age, mode of delivery (elective Cesarean section before onset of labour with intact membranes, other Cesarean section, spontaneous vaginal birth, operative vaginal delivery), use of invasive fetal monitoring (scalp electrode or scalp blood sampling for pH), breastfeeding, and postnatal ZDV prophylaxis.

Approximate confidence intervals (CI) were calculated for odds ratios (OR) and proportions. Proportions were compared by the χ2 or Fisher's exact test. Logistic regression was performed using STATISTICA for Macintosh (StatSoft, Inc, Tulsa, Oklahoma, USA).

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A total of 494 children were born during the study period (excluding six randomly chosen members of twin pairs), and 414 (84%) of them had their infection status determined. All twins were concordant (five were not infected, one was indeterminate). Infection status was indeterminate in nine children because of early non-HIV-related death, in 48 because of loss to follow-up, and in 23 because of parental dissent to venipuncture although clinical follow-up was possible. Eighteen of these latter children were younger than 12 months old. Except for ZDV use, distribution of risk factors was similar among children with known and indeterminate infection status. ZDV use was over-represented amongst those with indeterminate infection status because of the younger age of these children [21 indeterminate out of 76 (28%) after ZDV exposure versus 59 (14%) out of 417 without ZDV]. Sixty-seven out of 414 children were found to be HIV-infected, giving a transmission rate of 16.2% (95% CI, 13.0–18.5).

After elective Cesarean section, which was performed in 117 cases, transmission rate was 6% (seven out of 117; 95% CI, 2–12), compared with 20% (59 out of 295; 95% CI, 16–23) for other delivery modes (OR, 0.25; 95% CI, 0.11–0.58; P < 0.001). Twenty per cent of children were born in centres offering elective Cesarean section routinely, and 76% of those were in fact delivered by Cesarean section. Frequency of Cesarean section in the other centres was 16%. Stratified analysis according to type of centre by the Mantel-Haenszel method yielded no evidence for a modification of the effect of elective Cesarean section by the type of centre, and gave a combined OR of 0.33 (95% CI, 0.13–0.88; P < 0.025). The influence of obstetric factors on transmission rate is summarized in Table 1. Taking together all children who had an invasive procedure including vacuum or forceps delivery or invasive fetal monitoring, the transmission rate for this group was 27% (14 out of 52; 95% CI, 16–41). The intermediate group, born by spontaneous vaginal delivery or non-elective Cesarean section and with documented absence of invasive fetal monitoring, had a transmission rate of 18% (39 out of 218; 95% CI, 13–23). Finally, the children with the least invasive mode of delivery, namely elective Cesarean section, had, as stated above, a transmission rate of 6%. Thus, a direct relationship between transmission rate and invasiveness of the delivery process could be demonstrated (χ2 test for trend, P < 0.001).

Table 1
Table 1
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ZDV use during pregnancy was reported for 57 women: in three women as a maternal therapy (in one case in combination with lamivudine), and in 54 women for prevention of mother-to-child transmission. Median duration of ZDV use was 17 weeks (range, 1–33 weeks). Intrapartum intravenous ZDV was used in 66 cases and postnatal ZDV prophylaxis in 68 children. Altogether, 76 mother-child pairs had any ZDV exposure, and 45 of these had a complete prophylactic regimen defined as antenatal ZDV starting before 34 weeks of pregnancy, intravenous intrapartum application and postnatal prophylaxis for 6 weeks. Of the 89 children born after publication of the recommendations for general prophylaxis, 69 (78%) had some form of ZDV exposure, and 44 (49%) received a complete regimen. Transmission rate was 7% (four out of 55) in children with any ZDV exposure and known infection status compared with 17% in the absence of ZDV (OR, 0.37; 95% CI, 0.13–1.07; not significant). Two (7%) out of 30 children were infected after a complete ZDV regimen, one of them by a ZDV-resistant strain of HIV [10]. Because transmission rates were identical after complete or incomplete prophylaxis, the variable ‘any ZDV exposure’ was chosen for multivariate analysis.

Other factors found to be associated with transmission rate (Table 2) were maternal HIV-related symptoms and a history of one or more previous miscarriages or induced abortions. The number of these events in a particular women had no influence on the size of this effect. Maternal age, parity, drug use, sex of infant, gestational age and breastfeeding [transmission rate for children ever breastfed, 16% (five out of 31), versus 16% (59 out of 378) in those never breastfed] had no association with transmission rate. Many of the risk factors analysed showed considerable association amongst themselves. Mothers with elective Cesarean section had more ZDV use (20 versus 5%; P < 0.001), more HIV-related symptoms (13 versus 7%; P = 0.004), were more often primiparous (78 versus 61%; P = 0.002) and less likely to breastfeed (1 versus 10%; P = 0.001) than their counterparts, but did not differ by age, history of drug use, and previous miscarriage or induced abortion. Mother-child pairs who, despite delivery after publication of recommendations for prophylaxis, did not receive ZDV had less elective Cesarean section (26 versus 57%; P < 0.05), fewer HIV-related symptoms (6 versus 16%), and were breastfed more often (21 versus 0%; P < 0.001) than their counterparts, but did not differ by age, parity, history of drug use, and previous miscarriage or induced abortion. Adjustment for all these factors by logistic regression (Table 2) strengthened the association with maternal HIV-related symptoms, confirmed an independent, statistically highly significant effect of elective Cesarean section, and did not alter the effect of ZDV, which did not reach statistical significance.

Table 2
Table 2
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The combined effect of ZDV use and elective Cesarean section resulted in the absence of mother-to-child transmission in 31 consecutive children (Table 3). There appeared to be an independent and additive effect on transmission rate. Risk differences for both ZDV use and elective Cesarean section were not significantly different between strata, so no effect modification could be demonstrated. The pooled risk difference for ZDV use was 7.6% (95% CI, 0–16) and for elective Cesarean section 13.0% (95% CI, 5–22).

Table 3
Table 3
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The most striking finding of the present study was that the combination of elective Cesarean section with ZDV prophylaxis seemed to eliminate vertical transmission altogether, with 31 consecutively born infants shown to be not infected. Although numbers after combined prophylaxis are still small (upper limit of the 95% CI is 11%, a rate observed after ZDV prophylaxis alone) and the potential biases of an observational study cannot be ruled out, an additive protective effect of the two interventions is biologically plausible.

Soon after mother-to-child transmission of HIV was recognized, some obstetricians suggested a possible preventive effect of elective Cesarean section. Despite a lack of scientific data, as early as in 1985 some obstetric centres in Switzerland started to routinely offer delivery by elective Cesarean section by 38 weeks of pregnancy to all their HIV-infected pregnant women, whereas other centres chose to leave their obstetric practice unaffected by the presence of HIV infection. During the following decade it became increasingly clear that a substantial proportion of vertical infections do indeed take place at the time around delivery, and that the potential pathways of intrapartum virus transmission, namely transplacental maternofetal haemorrhage during labour, swallowing of cervicovaginal secretions or blood during birth, or direct contact of infectious fluid with mucous membranes or traumatic skin lesions in the birth canal, could theoretically be circumvented by elective Cesarean section [11]. In the present analysis of the Swiss cohort, a very clear reduction in transmission rate after elective Cesarean section was found, contrasting with an increase associated with the use of invasive procedures. Other maternal factors found to influence transmission rate were HIV-related symptoms, as already reported in many other studies [11], and a history of previous miscarriage or induced abortion. This latter finding was unexpected and cannot readily be explained. Unfortunately, data on maternal CD4+ cell counts and viral load were too incomplete to allow an adjustment for these known predictors.

A reduction of transmission rate after Cesarean section has been observed in the much larger European Collaborative Study [12], but not in the equally large French Multicentre Study [3]. Most other studies yielded inconclusive results, except for a small cohort from South Africa showing a reduction of marginal statistical significance [2]. The results of a meta-analysis were mainly influenced by the two very large European studies and indicated a small protective effect of Cesarean section [13]. The power of this analysis was limited by the impossibility of distinguishing between elective and emergency Cesarean sections and by methodological differences among studies, including indications for Cesarean sections as well as the recording of practical details such as the timing of the intervention in relation to labour and rupture of membranes. Our study is unique in that a large proportion of women had Cesarean section for the only reason of being HIV-positive and the intervention was prospectively documented as having occurred before labour and with intact membranes.

The recommendation for ZDV prophylaxis of mother-to-child transmission of HIV had a very good uptake among physicians in Switzerland. However, a substantial minority of pregnant women were reluctant to take the drug before the immediate intrapartum period or refused it altogether. Most of them were in relatively good health and seemed to have a critical attitude towards modern medicine, as reflected by their surprisingly high rate (21%) of breastfeeding against medical advice. Complete or partial ZDV prophylaxis resulted in a reduction of transmission rate from 17 to 7%.

Transmission despite ZDV prophylaxis can occur in the presence of resistant HIV [10,14] or be associated with a lack of antenatal decrease in maternal viral load [15]. This latter finding of a small cohort study was, however, not completely confirmed by the viral load analysis of the ACTG 076 study [16], suggesting a post-exposure preventive effect of ZDV in the fetus or new-born as an additional mechanism. In this case, the size of the viral inoculum, given by the concentration of infective virus in the transmitting fluid times the volume inoculated, may be crucial in peripartum transmission. If elective Cesarean section effectively reduces exposure to infectious fluids, then an additive protective effect to ZDV prophylaxis appears likely.

A definite answer to the question of whether and to what extent elective Cesarean section protects from perinatal HIV transmission and how such a protective effect would be affected by the presence or absence of ZDV prophylaxis can only be given by a randomized controlled trial. In addition, only an intervention trial can evaluate the potential risks of routine Cesarean section to maternal health. An international randomized mode of delivery trial enrolling women accepting or refusing antiretroviral prophylaxis is now ongoing in Europe. Depending on the results of this trial, elective Cesarean section might prove to be a valuable alternative or adjunct in the prevention of mother-to-child transmission of HIV, especially for women fearing potential toxic effects of ZDV or combinations of antiretroviral agents towards the fetus and newborn.

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The authors thank J. Micallef for editing assistance.

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Principal collaborators of the Swiss Neonatal HIV Study Group

J.J. Cheseaux, B. Vaudaux, C-L. Fawer (University Children's Hospital, Lausanne); P. Birrer (University Children's Hospital, Bern); H.E. Gnehm (Children's Hospital, Aarau); G. Schubiger (Children's Hospital, Luzern); J. Klingler (Children's Hospital, Biel); U. Hunziker (Division of Paediatrics, Kantonsspital, Winterthur); H.F. Kuchler (Division of Paediatrics, Hôpital Cantonal, Sion); M.P. Gianinazzi (Division of Paediatrics, Ospedale Civico, Lugano); U. Bühlmann (Division of Paediatrics, Stadtspital Triemli, Zürich); S. Suter (University Children's Hospital, Genève); U.B. Schaad (University Children's Hospital, Basel); G. Spoletini (University Women's Hospital, Lausanne, now Regional Hospital La Chaux-de-Fonds); K. Rohling (University Women's Hospital, Zürich); J. Böni, J. Jendis, Z. Tomasik (National Centre for Retroviruses, University of Zürich); L. Perrin (Laboratory for Viral Serology, University Hospital Genève); P. Erb (Institute for Medical Microbiology, University of Basel); M. Künzel, I. Felber, M. Holzherr, G. Schneidewind (Study administration, Kantonsspital, St Gallen). Cited Here...

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Rancillo, L; Bucceri, A; Tulisso, S; Scolfaro, C; Riva, C; Vierucci, A; de Luca, M; Farina, S; Fundaro, C; Genovese, O; Mercu, G; Forni, G; Stegagno, M; Falconieri, P; Zuccotti, G; Riva, E; Cellini, M; Baraldi, C; Consolini, R; Palla, G; Ruggeri, M; Pignata, C; Guarino, A; Osimani, P; Metri, A; Antonellini, A; Benaglia, G; Romano, A; Dallacasa, P; De Mattia, D; Caselli, D; Boni, S; Dell'Erba, G; Bassanetti, F; Sticca, M; Timpano, C; Magnani, C; Salvatore, C; Gambaretto, G; Lipreri, R; Tornaghi, R; Pinzani, R; Cecchi, M; Bezzi, T; Battisti, L; Bresciani, E; Gattinara, G; Berrino, R; Pellegatta, A; Mazza, A; Baldi, F; Micheletti, E; Ruga, E; Altobelli, R; Deiana, M; Colnaghi, C; Tarallo, L; Tondo, U; Anastasio, E; Duse, M; Chiriaco, P; Contardi, I; Ruggeri, C; Ibba, P; Scott, G; Hutto, C; O'Sullivan, M; Malmsberry, A; Willoughby, A; Burns, D; Goedert, J; Landesman, S; Minkoff, H; Mendez, H; Holman, S; Rubinstein, A; Durako, S; Muenz, L; Goodwin, S; Nesheim, S; Lindsay, M; Clark, S; Lee, F; Nahmias, A; Sawyer, M; Vink, P; Farley, J; Alger, L; Abrams, E; Bamji, M; Lambert, G; Schoenbaum, E; Thea, D; Thomas, P; Weedon, J; Palumbo, P; Bardeguez, A; Denny, T; Oleske, J; Simonds, R; Orloff, S; Ethier-Ives, J; Rogers, M; Schluchter, M; Kutner, M; Kaplan, S; Kattan, M; Lipshultz, S; Mellins, R; Shearer, W; Peavy, H; Sopko, G; Sloand, E; Wu, M; Kind, C; Nadal, D; Rudin, C; Siegrist, CA; Wyler, CA; Cheseaux, JJ; Aebi, C; Gnehm, H; Schubiger, G; Klingler, J; Hunziker, U; Kuchler, H; Gianinazzi, M; Buhlmann, U; Rudin, C; Biedermann, K; Lauper, U; Irion, O; Brunelli, A; Spoletini, G; Schreyer, A; Kind, C; Hosli, I; Saurenmann, E; Drack, G; Isenschmid, M; Poorbeik, M; Schupbach, J; Perrin, L; Erb, P; Joller, H; Bryson, Y; Dillon, M; Nielsen, R; Boyer, P; Liao, D; Keller, M; Deveikis, A; Kovacs, A; Stek, A; Chan, L; Rother, C; Khoury, M; Diaz, C; Pacheco-Acosta, E; Tuomala, R; Cooper, E; Mesthene, D; Pitt, J; Higgins, A; Mendez, H; Moroso, G; Rich, K; Turpin, D; Cooper, N; Fowler, M; Nugent, R; Smeriglio, V; McKinlay, S; Kalish, L; Ellis, S; Andiman, W; Simpson, B
New England Journal of Medicine, 340(): 977-987.

Child Care Health and Development
Disclosure of diagnosis and planning for the future in HIV-affected families in Europe
Thorne, C; Newell, ML; Peckham, CS
Child Care Health and Development, 26(1): 29-40.

Schweizerische Medizinische Wochenschrift
Clinical epidemiology and research on HIV infection in Switzerland: the Swiss HIV Cohort Study 1988-2000
Sudre, P; Rickenbach, M; Taffe, P; Janin, P; Volkart, AC; Francioli, P
Schweizerische Medizinische Wochenschrift, 130(): 1493-1500.

Jama-Journal of the American Medical Association
Understanding the timing of HIV transmission from mother to infant
Kourtis, AP; Bulterys, M; Nesheim, SR; Lee, FK
Jama-Journal of the American Medical Association, 285(6): 709-712.

American Journal of Obstetrics and Gynecology
Cesarean delivery for HIV-infected women: recommendations and controversies
Jamieson, DJ; Read, JS; Kourtis, AP; Durant, TM; Lampe, MA; Dominguez, KL
American Journal of Obstetrics and Gynecology, 197(3): S96-S100.
Journal of Virology
The trophoblastic epithelial barrier is not infected in full-term placentae of human immunodeficiency virus-seropositive mothers undergoing antiretroviral therapy
Tscherning-Casper, C; Papadogiannakis, N; Anvret, M; Stolpe, L; Lindgren, S; Bohlin, AB; Albert, J; Fenyo, EM
Journal of Virology, 73(): 9673-9678.

British Medical Journal
Vertical transmission rates for HIV in the British Isles: estimates based on surveillance data
Duong, T; Ades, AE; Gibb, DM; Tookey, PA; Masters, J
British Medical Journal, 319(): 1227-1229.

Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts
Nielsen, SD; Jeppesen, DL; Kolte, L; Clark, DR; Sorensen, TU; Dreves, AM; Ersboll, AK; Ryder, LP; Valerius, NH; Nielsen, JO
Blood, 98(2): 398-404.

American Journal of Obstetrics and Gynecology
Scheduled cesarean delivery and the prevention of human immunodeficiency virus transmission: A survey of practicing obstetricians
Rowland, BL; Vermillion, ST; Soper, DE
American Journal of Obstetrics and Gynecology, 185(2): 327-330.
Journal of Infectious Diseases
Fetal feline immunodeficiency virus is prevalent and occult
Rogers, AB; Hoover, EA
Journal of Infectious Diseases, 186(7): 895-904.

European Journal of Obstetrics Gynecology and Reproductive Biology
HIV detection in amniotic fluid samples - Amniocentesis can be performed in HIV pregnant women?
Maiques, V; Garcia-Tejedor, A; Perales, A; Cordoba, J; Esteban, RJ
European Journal of Obstetrics Gynecology and Reproductive Biology, 108(2): 137-141.
PII S0301-2115(02)00405-0
Gynecologie Obstetrique & Fertilite
Second pregnancies in HIV-1-infected women. A prospective monocentric study
Monpoux, F; Delotte, J; Galiba, E; de Smet, S; Durant, J; Boutte, P; Bongain, A
Gynecologie Obstetrique & Fertilite, 36(4): 379-385.
Schweizerische Medizinische Wochenschrift
Pulmonary diseases in HIV-infected children
Nadal, D
Schweizerische Medizinische Wochenschrift, 128(): 1375-1384.

Interventions to prevent vertical transmission of HIV-1: effect on viral detection rate in early infant samples
Dunn, DT; Simonds, RJ; Bulterys, M; Kalish, LA; Moye, J; de Maria, A; Kind, C; Rudin, C; Denamur, E; Krivine, A; Loveday, C; Newell, ML
AIDS, 14(): 1421-1428.

The cost-effectiveness of elective Cesarean delivery for HIV-infected women with detectable HIV RNA during pregnancy
Mrus, JM; Goldie, SJ; Weinstein, MC; Tsevat, J
AIDS, 14(): 2543-2552.

Short-term risk of disease progression in HIV-1-infected children receiving no antiretroviral therapy or zidovudine monotherapy: a meta-analysis
Dunn, DT; Gibb, DM; Duong, T; Babiker, AG; Bulterys, M; Gabiano, C; Galli, L; Giaquinto, C; Gray, L; Harris, DR; Hughes, M; McKinney, R; Mofenson, L; Moye, J; Newell, ML; Pahwa, S; Palumbo, P; Rudin, C; Schluchter, M; Sharland, M; Shearer, W; Thompson, B; Tookey, P
Lancet, 362(): 1605-1611.

American Journal of Health-System Pharmacy
Update on preventing vertical transmission of HIV type 1
Chen, F; Pau, AK; Piscitelli, SC
American Journal of Health-System Pharmacy, 57(): 1616-1623.

An effective and safe protocol involving zidovudine and caesarean section to reduce vertical transmission of HIV-1 infection
Grosch-Worner, I; Schafer, A; Obladen, M; Maier, RF; Seel, K; Feiterna-Sperling, C; Weigel, R
AIDS, 14(): 2903-2911.

Journal of Medical Screening
Impact of antenatal HIV screening to prevent HIV infection in children in Norway 1987-99
Aavitsland, P; Nilsen, O; Lystad, A; Bjorndal, A
Journal of Medical Screening, 9(2): 57-59.

Antiretroviral therapy, fat redistribution and hyperlipidaemia in HIV-infected children in Europe
La Rovere; Pellegatta; Sticca; Bezzi; Basetti, D; Rosso, R; Ferrando, S; Cristina; Lipreri; Merlo; Bianchi; Schneider; Brambilla, P; Guarino; Giaquinto, C; Giacomet, V; Ebo; Romano; Maccabruni, A; Consolini; Castelli, G; Cursi; Palma; Anzidei; Chiodi; Gabiano, C; Garetto; Mazza; Rabusin; Bohlin, AB; Mur, A; Botet, FA; de Jose, I; Ciria, L; Grosch-Worner, I; Marczynska, M; Nadal, D; Zucol, F; Wyler, CA; Egli, D; Kind, C; Rudin, C; Cheseaux, JJ; Duppenthaler, A; Aebi, C
AIDS, 18(): 1443-1451.
Medicina Clinica
Vertical transmission of HIV-1. How far can it be reduced?
Pena, JM
Medicina Clinica, 114(8): 297-298.

Schweizerische Medizinische Wochenschrift
HIV infections in children: Is the horizon starting to look clearer?
Nadal, D
Schweizerische Medizinische Wochenschrift, 129(): 30-33.

Primary Care
Risk assessment
Andolsek, KM; Kelton, GM
Primary Care, 27(1): 71-+.

Clinical Infectious Diseases
Detection of a drug-resistant human immunodeficiency virus variant in a newly infected heterosexual couple
Romano, L; Venturi, G; Vivarelli, A; Galli, L; Zazzi, M
Clinical Infectious Diseases, 34(1): 116-117.

Perinatal Medicine of the New Millennium
Interventions to reduce HIV mother-to-child transmission
Domenech, BMDT
Perinatal Medicine of the New Millennium, (): 1280-1284.

Meeting international goals in child survival and HIV/AIDS
Walker, N; Schwartlander, B; Bryce, J
Lancet, 360(): 284-289.

Third World Congress on Controversies in Obstetrics Gynecology & Infertility
The role of cesarean section in the prevention of mother-to-child transmission of HIV
Minkoff, H
Third World Congress on Controversies in Obstetrics Gynecology & Infertility, (): 281-288.

European Journal of Medical Research
German-Austrian recommendations for HIV-therapy in pregnancy and in HIV-exposed newborn - Update 2005
Buchholz, B; Beichert, M; Marcus, U; Grubert, T; Gingelmaier, A; Haberl, A; Schmied, B; Brockmeyer, N
European Journal of Medical Research, 11(9): 359-376.

Acta Paediatrica
Zidovudine prophylaxis and perinatal HIV-1 transmission
Zuccotti, GV; Ferraris, G; Agostoni, C; Rancilio, L; Ravizza, M; Bucceri, AM; Riva, E; Marini, A
Acta Paediatrica, 88(): 1298.

Monatsschrift Kinderheilkunde
Recommendations for antiretroviral therapy in HIV-infected children. Completely revised and updated consensus statement of the Pediatric AIDS Committee (PAAD) and the German Society for Pediatric Infectology
Niehues, T; Wintergerst, U; Funk, M; Notheis, G
Monatsschrift Kinderheilkunde, 149(): 1372-+.

Swiss Medical Weekly
High risk behaviour and fertility desires among heterosexual HIV-positive patients with a serodiscordant partner - two challenging issues
Panozzo, L; Battegay, M; Friedl, A; Vernazza, PL
Swiss Medical Weekly, 133(): 124-127.

Archives of Disease in Childhood
Sudden infant death syndrome in infants born to HIV-infected and opiate-using mothers
Kahlert, C; Rudin, C; Kind, C
Archives of Disease in Childhood, 92(): 1005-1008.
Antiretroviral therapies in pregnancy: maternal, fetal and neonatal effects
Lorenzi, P; Spicher, VM; Laubereau, B; Hirschel, B; Kind, C; Rudin, C; Irion, O; Kaiser, L
AIDS, 12(): F241-F247.

New England Journal of Medicine
Elective cesarean delivery to reduce the transmission of HIV
Riley, LE; Greene, MF
New England Journal of Medicine, 340(): 1032-1033.

American Journal of Obstetrics and Gynecology
Bloodless cesarean delivery and perinatal transmission of the human immunodeficiency virus - Reply
Towers, CV; Asrat, T
American Journal of Obstetrics and Gynecology, 180(5): 1308-1309.

Early Human Development
Epidemiology of HIV infection in the newborn
Thorne, C; Newell, ML
Early Human Development, 58(1): 1-16.

Fetal Diagnosis and Therapy
Effects of intrapartum zidovudine therapy on fetal heart rate parameters in women with human immunodeficiency virus infection
Blackwell, SC; Sahai, A; Hassan, SS; Treadwell, MC; Tomlinson, MW; Jones, TB; Sorokin, Y
Fetal Diagnosis and Therapy, 16(6): 413-416.

Public Health
Meta-analysis of published studies or meta-analysis of individual data? Caesarean section in HIV-positive women as a study case
Angelillo, IF; Villari, P
Public Health, 117(5): 323-328.
Human Reproduction
Encouraging results despite complexity of multidisciplinary care of HIV-infected women using assisted reproduction techniques
Ohl, J; Partisani, M; Wittemer, C; Lang, JM; Viville, S; Favre, R
Human Reproduction, 20(): 3136-3140.
Interventions to reduce mother-to-child transmission of HIV infection: new developments and current controversies
Gibb, DM; Tess, BH
AIDS, 13(): S93-S102.

Journal of Infectious Diseases
Prospective evaluation of amplification-boosted ELISA for heat-denatured p24 antigen for diagnosis and monitoring of pediatric human immunodeficiency virus type 1 infection
Nadal, D; Boni, J; Kind, C; Varnier, OE; Steiner, F; Tomasik, Z; Schupbach, J
Journal of Infectious Diseases, 180(4): 1089-1095.

T-lymphocyte maturation abnormalities in uninfected newborns and children with vertical exposure to HIV
Clerici, M; Saresella, M; Colombo, F; Fossati, S; Sala, N; Bricalli, D; Villa, ML; Ferrante, P; Dally, L; Vigano, A
Blood, 96(): 3866-3871.

Infections in Medicine
Preventing HIV transmission during pregnancy
Shah, SS; McGowan, JP
Infections in Medicine, 18(2): 94-+.

Clinical Chemistry and Laboratory Medicine
Simultaneous determination of HIV antibodies, hepatitis C antibodies, and hepatitis B antigens in dried blood spots a feasibility study using a multi-analyte immunoassay
Lukacs, Z; Dietrich, A; Ganschow, R; Kohlschutter, A; Kruithof, R
Clinical Chemistry and Laboratory Medicine, 43(2): 141-145.
Plos Medicine
Maternal-fetal microtransfusions and HIV-1 mother-to-child transmission in Malawi
Kwiek, JJ; Mwapasa, V; Milner, DA; Alker, AP; Miller, WC; Tadesse, E; Molyneux, ME; Rogerson, SJ; Meshnick, SR
Plos Medicine, 3(1): 70-75.
ARTN e10
Archives of Gynecology and Obstetrics
Human immunodeficiency virus and pregnancy
Reshi, P; Lone, IM
Archives of Gynecology and Obstetrics, 281(5): 781-792.
Jama-Journal of the American Medical Association
Perinatal HIV-1 transmission - Interaction between zidovudine prophylaxis and mode of delivery in the French Perinatal Cohort
Mandelbrot, L; Le Chenadec, J; Berrebi, A; Bongain, M; Benifla, JL; Delfraissy, JF; Blanche, S; Mayaux, MJ
Jama-Journal of the American Medical Association, 280(1): 55-60.

Journal of Infectious Diseases
Codon 215 mutations in human immunodeficiency virus-infected pregnant women
Kully, C; Yerly, S; Erb, P; Kind, C; Krautheim, A; Perrin, L; Rudin, C
Journal of Infectious Diseases, 179(3): 705-708.

Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial
Parazzini, F; Ricci, E; Di Cintio, E; Chiaffarino, F; Pardi, G; Parazzini, F; Bortolus, R; D'Oro, LC; Biraghi, P; Bucceri, A; Ravizza, M; Grossi, E; Muggiasca, ML; Tibaldi, C; Prati, A; Iasci, A; Aronica, E; Ceccarelli, E; Frigerio, L; Borlone, P; Stagnizza, M; Agnoletto, V; Tognoni, G; Lazzrin, A; Massobrio, M; Garzetti, GG; Ciavattini, A; Mosca, S; Greco, P; Vimercati, A; Guerra, B; Bianchi, S; Bovicelli, L; Prati, E; Innocenti, TA; Fiscella, A; Bucceri, A; Grossi, E; Rossi, G; Rancilio, L; Ferraris, G; Vignali, M; Muggiasca, ML; Semprini, AE; Ravizza, M; Castagna, C; Della Torre, M; Martinelli, P; Sansone, M; di Lenardo, L; Russolo, A; Rubino, E; Lo Bue, G; Maccabruni, A; Arlandi, L; Citernesi, A; Villa, P; Mancuso, S; Pachi, A; Scaravelli, G; Tibaldi, C; Benedetto, C; Ziarati, N; Gabiano, C; Alberico, S; Franchi, M; Zanconato, G; Fedele, L; Newell, ML; Bailey, A; Peckham, C; Darbyshire, J; Sanchez, E; Semprini, AE; Leyes, M; Ciria, LM; Coll, O; Fortuny, C; Bogunya, JM; Paya, A; Mur, A; Casellas, M; Lain, J; Anzen, B; Lindgren, S; Rudin, C; Irion, O; Bewley, S; Kennedy, J; Mandelbrot, L; Bazin, B; Aboulker, JP; Crenn-Hebert, C; Tudal, CF; Bech, A; Lobut, R; Chemla, JP; Milliez, J; Courpotin, C; Mandelbrot, L; Firtion, G; Benifla, JL; Ottenwalter, A; Vilmer, E; Hocke, C; Douard, D; Berrebi, A; Tricoire, J; Pauly, I; Le Lorier, B; Bongain, A; Monpoux, F; Cravello, L; Perrimond, H; Newell, ML; Darbyshire, J; Peckham, C; Coll, O; Sanchez, E; Mandelbrot, L; Aboulker, JP; Bazin, B; Blanche, S
Lancet, 353(): 1035-1039.

Risk factors for postnatal mother-child transmission of HIV-1
Embree, JE; Njenga, S; Datta, P; Nagelkerke, NJD; Ndinya-Achola, JO; Mohammed, Z; Ramdahin, S; Bwayo, JJ; Plummer, FA
AIDS, 14(): 2535-2541.

Journal of Clinical Anesthesia
Human immunodeficiency virus in the parturient
Kuczkowski, KM
Journal of Clinical Anesthesia, 15(3): 224-233.
Deutsche Medizinische Wochenschrift
HIV therapy in pregnancy. German-Austrian guidelines (May 2001)
Ahr, A; Arasteh, K; Bakare, N; Baumgartner, EM; Beichert, M; Bergmann, F; Brockmeyer, N; Buchholz, B; Buescher, U; Clad, A; Diedrich, K; Dunsch, D; Engelbach, U; Faul-Burbe, C; Friese, K; Funke, AM; Gingelmaier, A; Golz, J; Groeger, S; Grosch-Worner, I; Grubert, T; Gute, P; Haberl, A; Heise, W; Helm, M; Hillenbrand, H; Hollwitz, B; Hower, M; Jaeger, H; Knechten, H; Kremer, H; Kuhlmann, B; Linde, R; Locher, L; Marcus, U; Notheis, G; Nzimegne, S; Obladen, M; Plettenberg, A; Puch, K; Schaefer, C; Schafer, A; Schmidt, B; Schmied, B; Seyberth, HW; Sonnenberg-Schwan, U; Trompke, R; Ulmer, A; Vocks-Hauck, M; Weigel, M; Weiler, G; Weitner, L
Deutsche Medizinische Wochenschrift, 128(): S19-S31.

Deutsche Medizinische Wochenschrift
German-Austrian recommendations for HIV treatment during pregnancy and for newborns exposed to HIV - Update 2008
Deutsche Medizinische Wochenschrift, 134(): S40-S54.
Combination antiretroviral therapy and duration of pregnancy
Aebi, C; Battegay, M; Bernasconi, E; Biedermann, K; Cheseaux, JJ; Drack, G; Erb, P; Flepp, M; Francioli, P; Furrer, HJ; Gianinazzi, MP; Gyr, T; Hirschel, B; Hosli, I; Hug, I; Irion, O; Keller, K; Kind, C; Laubereau, B; Lauper, U; Lorenzi, P; Matter, L; Nadal, D; Perrin, L; Rickenbach, M; Rudin, C; Schreyer, A; Schupbach, J; Telenti, A; Vernazza, P; Wolf, K; Wunder, D; Wyler, CA; Giaquinto, C; Ruga, E; De Rossi, A; Grosch-Worner, I; Seel, K; Schafer, A; Mok, J; Johnstone, F; Jimenez, J; Garcia-Rodriguez, MC; Bates, I; de Jose, I; Hawkins, F; de Gevara, CL; Pena, JM; Garcia, JG; Lopez, JRA; Asensi-Botet, F; Otero, MC; Perez-Tamarit, D; Ridaura, S; Gregori, P; de la Torre, R; Scherpbier, H; Kreyenbroek, M; Boer, K; Bohlin, AB; Lindgren, S; Ehrnst, A; Belfrage, E; Lidman, K; Christensson, B; Levy, J; Hainaut, M; Peltier, A; Barlow, P; Wibaut, S; Lecroart, MC; Ferrazin, A; Bassetti, D; De Maria, A; Gotta, C; Mur, A; Paya, A; Vinolas, M; Lopez-Vilchez, MA; Martinez-Gomez, P; Carreras, R; Coll, O; Fortuny, C; Boguna, J; Caro, MC; Canet, Y; Pardi, G; Ravizza, M; Guerra, B; Lanari, M; Bianchi, S; Bovicelli, L; Prati, E; Duse, M; Scaravelli, G; Stegagno, M; De Santis, M; Semprini, AE; Savasi, V; Vigano, A; Probizer, FR; Maccabruni, A; Bucceri, A; Rancilio, L; Taylor, GP; Lyall, H; Penn, Z; Valerius, NH; Martinelli, P; Buffolano, W; Sansone, M; Tibaldi, C; Ziarati, N; Benedetto, C; Niemiec, T; Horban, A
AIDS, 14(): 2913-2920.

American Family Physician
Obstetric care in patients with HIV disease
Krist, AH
American Family Physician, 63(1): 107-116.

AIDS Research and Human Retroviruses
Clinical care issues for women living with HIV and AIDS in the United States
Marlink, R; Kao, H; Hsieh, E
AIDS Research and Human Retroviruses, 17(1): 1-33.

Yonsei Medical Journal
Anesthetic considerations for the HIV-infected pregnant patient
Kuczkowski, KM
Yonsei Medical Journal, 45(1): 1-6.

International Journal of Gynecology & Obstetrics
Scheduled cesarean delivery and the prevention of vertical transmission of HIV infection
International Journal of Gynecology & Obstetrics, 73(3): 279-281.

Journal of Clinical Anesthesia
Anesthetic management of the parturient with fever and infection
Kuczkowski, KM; Reisner, LS
Journal of Clinical Anesthesia, 15(6): 478-488.
European Journal of Medical Research
German-Austrian recommendations for HIV-therapy in pregnancy - Update May 2003
Buchholz, B; Grubert, T; Marcus, U; Beichert, M; Gingelmaier, A; Brockmeyer, NH
European Journal of Medical Research, 9(6): 287-303.

Jama-Journal of the American Medical Association
Perinatal transmission of HIV in women receiving zidovudine - Abstract and commentary
Mofenson, LM
Jama-Journal of the American Medical Association, 280(6): 569-570.

Journal of Infectious Diseases
Genital tract human immunodeficiency virus type 1 (HIV-1) shedding and inflammation and HIV-1 env diversity in perinatal HIV-1 transmission
Panther, LA; Tucker, L; Xu, C; Tuomala, RE; Mullins, JI; Anderson, DJ
Journal of Infectious Diseases, 181(2): 555-563.

Journal of Antimicrobial Chemotherapy
Prevention of perinatal HIV transmission during pregnancy
McGowan, JP; Shah, SS
Journal of Antimicrobial Chemotherapy, 46(5): 657-668.

Prenatal and Neonatal Medicine
Recommendations for the management of HIV-infected women and their infants - a European consensus
Tovo, PA; Newel, ML; Mandelbrot, L; Semprini, E; Giaquinto, C
Prenatal and Neonatal Medicine, 4(1): 3-17.

Obstetrics and Gynecology
Scheduled cesarean delivery and the prevention of vertical transmission of HIV infection
Obstetrics and Gynecology, 94(2): 1-3.

Journal of Infectious Diseases
Investigation of HIV in amniotic fluid from HIV-infected pregnant women at full term
Mohlala, BKF; Tucker, TJ; Besser, MJ; Williamson, C; Yeats, J; Smit, L; Anthony, J; Puren, A
Journal of Infectious Diseases, 192(3): 488-491.

Indian Journal of Dermatology Venereology & Leprology
Prevention of mother-to-child transmission
Surjushe, A; Maniar, J
Indian Journal of Dermatology Venereology & Leprology, 74(3): 200-207.

Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis
3 '-azido-3 '-deoxythymidine (AZT) transplacental perfusion kinetics and DNA incorporation in normal human placentas perfused with AZT
Olivero, OA; Parikka, R; Poirier, MC; Vahakangas, K
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 428(): 41-47.

Emerging Infectious Diseases
HIV postexposure prophylaxis in the 21st century
Henderson, DK
Emerging Infectious Diseases, 7(2): 254-258.

Prevention of perinatal HIV transmission - Current status and future developments in anti-retroviral therapy
Kourtis, AP
Drugs, 62(): 2213-2220.

International Journal of Gynecology & Obstetrics
Breastfeeding and the risk of hepatitis C virus transmission
International Journal of Gynecology & Obstetrics, 66(3): 307-308.

Pregnancy and HIV infection: a European consensus on management
Newell, ML; Rogers, M
AIDS, 16(): S1-S18.

Canadian Medical Association Journal
Canadian consensus guidelines for the management of pregnancy, labour and delivery and for postpartum care in HIV-positive pregnant women and their offspring (summary of 2002 guidelines)
Burdge, DR; Money, DM; Forbes, JC; Walmsley, SL; Smaill, FM; Boucher, M; Samson, LM; Steben, M
Canadian Medical Association Journal, 168(): 1671-1674.

Current HIV Research
Mother-to-child transmission of HIV infection and its prevention
Thorne, C; Newell, ML
Current HIV Research, 1(4): 447-462.

European Journal of Medical Research
German-Austrian Recommendations for Hiv1-Therapy in Pregnancy and in Hiv1-Exposed Newborn - Update 2008
Buchholz, B; Beichert, M; Marcus, U; Grubert, T; Gingelmaier, A; Haberl, A; Schmied, B
European Journal of Medical Research, 14(): 461-479.

Current HIV Research
The Role of Co-Infections in Mother-to-Child Transmission of HIV
King, CC; Ellington, SR; Kourtis, AP
Current HIV Research, 11(1): 10-23.

Trends in Microbiology
HIV among women and children in Pakistan
Raees, MA; Abidi, SH; Ali, W; Khanani, MR; Ali, S
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Annals Academy of Medicine Singapore
Human Immunodeficiency Virus (HIV) in Pregnancy: A Review of the Guidelines for Preventing Mother-to-Child Transmission in Malaysia
Azwa, I; Khong, SY
Annals Academy of Medicine Singapore, 41(): 587-594.

Journal of Womens Health
Reproductive Outcomes of HIV Seropositive Women Treated by Assisted Reproduction
Nurudeen, SK; Grossman, LC; Bourne, L; Guarnaccia, MM; Sauer, MV; Douglas, NC
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Immune activation and normal levels of endogenous antivirals are seen in healthy adolescents born of HIV-infected mothers
Vigano, A; Saresella, M; Schenal, M; Erba, P; Piacentini, L; Tornaghi, R; Naddeo, V; Giacomet, V; Borelli, M; Trabattoni, D; Clerici, M
AIDS, 21(2): 245-248.
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Prevention of Mother-to-Child Transmission of HIV
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Duration of ruptured membranes and vertical transmission of HIV-1: a meta-analysis from 15 prospective cohort studies
The International Perinatal HIV Group,
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Current Opinion in Pediatrics
Transmission of HIV-1 from mother to infant
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Cost‐Effectiveness of Elective Cesarean Delivery in Human Immunodeficiency Virus–Infected Women
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Human Immunodeficiency Virus Infection in Pregnancy
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Back to Top | Article Outline

Epidemiology; vertical transmission; Cesarean section; zidovudine

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