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Absence of xenotropic murine leukemia virus-related virus in blood cells of men at risk for and infected with HIV

Kunstman, Kevin Ja; Bhattacharya, Tanmoyb; Flaherty, Johna; Phair, John Pa; Wolinsky, Steven Ma

doi: 10.1097/QAD.0b013e32833b76fb
Research Letters

Xenotropic murine leukemia virus-related virus has been detected in blood cells of patients with chronic fatigue syndrome and in 3.7% of healthy controls from the same geographic region. We evaluated 996 men who were participants in the Multicenter AIDS Cohort Study for xenotropic murine leukemia virus-related virus sequences in blood cells by means of a real-time quantitative PCR assay. Xenotropic murine leukemia virus-related virus was detected in none of the men on the basis of the absence of xenotropic murine leukemia virus-related virus DNA, suggesting that infection may be population-specific.

aNorthwestern University, Chicago, Illinois, USA

bSanta Fe Institute, Santa Fe, New Mexico, USA.

Received 7 January, 2010

Revised 21 April, 2010

Accepted 28 April, 2010

Correspondence to Dr Steven M. Wolinsky, MD, Department of Medicine, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Suite 900, Chicago, IL 60611, USA. Tel: +1 312 695 5090; fax: +1 312 695 5085; e-mail: s-wolinsky@northwestern.edu

© 2010 Lippincott Williams & Wilkins, Inc.