Among 127 HIV-infected women, the magnitude of high-density lipoprotein cholesterol (HDLc) increases after HAART initiation predicted the magnitude of concurrent decreases in inflammation biomarkers. After HAART initiation, changes in low-density lipoprotein cholesterol (LDLc) and inflammation were unrelated. In the same population, predicted risk of coronary heart disease, based upon levels of standard clinical risk factors, was similar before and after HAART. Thus, it remains unknown whether short-term treatment-related changes in standard risk factors may appreciably change risk of cardiovascular disease (CVD).
aDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York
bDepartment of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois
cAtherosclerosis Research Unit, University of Southern California, Los Angeles, California
dDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
eBlood Systems Research Institute, University of California, San Francisco, Departments of Laboratory Medicine and Medicine, San Francisco, California
fDepartment of Medicine, Georgetown University Medical Center, Washington, District of Columbia
gDepartment of Medicine, Albert Einstein College of Medicine, Bronx, New York
hDepartment of Medicine, University of California, San Francisco
iSan Francisco Veterans Affairs Medical Center, San Francisco, California
jDepartment of Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York
kDepartments of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, Vermont, USA.
Correspondence to Robert C. Kaplan, PhD, 1300 Morris Park Avenue, Belfer 1306C, Bronx, NY 10461, USA. Tel: +1 718 430 4076; e-mail: firstname.lastname@example.org
Received 4 December, 2012
Accepted 5 February, 2013