le Roux, Ingrid M.a; Tomlinson, Markb; Harwood, Jessica M.c; O’Connor, Mary J.d; Worthman, Carol M.e; Mbewu, Nokwanelea; Stewart, Jacquelinef; Hartley, Maryf; Swendeman, Dallasg; Comulada, W. Scottg; Weiss, Robert E.h; Rotheram-Borus, Mary Janei
For the past 10 years, evidence has been mounting on the importance of integrating HIV care with care of other health risks . In low-income and middle-income countries (LMICs), including South Africa, children's health is compromised not only by HIV, but also by the cumulative impact of poverty and related deficits from other infectious diseases, malnutrition, and maternal behaviors [2,3]. Yet, community health workers (CHWs) typically target single outcomes, such as HIV testing , tuberculosis (TB) adherence , securing a child grant , or maternal depression . In some LMICs, two to three different CHWs visit a household, each targeting a different health risk, but also replicating some components of the intervention. HIV-identified CHWs are also more likely to be rejected, given the stigma surrounding HIV .
In contrast, we trained CHWs to address multiple health behaviors. A home visiting intervention strategy for new mothers has repeatedly been demonstrated efficacious in the United States with significant short- and long-term outcomes when delivered by nurses [9–12]. The current global shortage of healthcare personnel in LMICs requires task-shifting from professionals to CHWs [13,14]. This study, set in Cape Town townships, evaluates the ability of home visits by CHWs to improve the well being of mothers and infants from pregnancy to the first 6 months of life for women living with HIV (WLH) and for all mothers. CHWs were trained in foundational skills to support behavioral change , specifically for HIV, alcohol use, infant malnutrition, and general maternal and child health.
We hypothesized that, compared to the standard care, WLH and all mothers in the Philani Intervention Program (PIP) would have improved maternal and child health and well being in five domains: adherence to HIV-related preventive acts [for WLH, including the tasks to prevent mother-to-child transmission (PMTCT)]; child health and nutrition (including alcohol use during pregnancy and breastfeeding); healthcare and monitoring; mental health; and social support .
The Institutional Review Boards of the University of California, Los Angeles (UCLA), Stellenbosch University, and Emory University approved the study .
Standard care and Philani Intervention Program conditions
The standard care condition consisted of access to healthcare at government clinics and hospitals, including rapid HIV testing and receipt of results. WLH were routinely offered HIV care, including testing for CD4 cell count; antiretroviral medication for WLH with low CD4 cell counts; maternal zidovudine (ZDV) from the 28th week of pregnancy and during delivery; nevirapine (NVP) for the mother during delivery and for the infant within 24 h of birth; and infant ZDV, formula tins, cotrimoxazole, and HIV PCR testing postbirth.
Philani Intervention Program
The PIP condition received antenatal and postnatal home visits by CHWs in addition to the clinic-based care that is standard care. CHWs were selected to have good social/communication skills, problem-solving skills, and thriving children (positive deviants). CHWs were trained for 1 month using an intervention manual, role-playing, and watching videotapes of common challenging situations that CHWs might face during home visits. All CHWs were trained in foundational skills in behavior change; application of key health information about HIV, alcohol use, malnutrition, and general maternal and child health; and coping with their own life challenges. CHWs worked 20 h weekly, and were paid R1250 a month (about 150 USD).
In accordance with standard procedures for an effectiveness trial, PIP was mounted by the local Philani Maternal, Child Health and Nutrition Program, a community-based organization. CHWs systematically visited every home in their assigned neighborhood, identified pregnant mothers, carried a scale to weigh infants, plotted weight on growth charts to identify underweight children, and transcribed outcomes from the government-issued Road-to-Health card. The antenatal messages concerned good maternal nutrition and preparing for breastfeeding; regular antenatal clinic attendance and danger signs; HIV testing, PMTCT tasks, and partner prevention strategies; and stopping alcohol use . The postnatal messages were breastfeeding and growth monitoring; medical adherence (immunizations, prevention for HIV-exposed children); infant bonding; and securing the child grant. The home visits were monitored in two ways: CHW handwritten notes; and CHWs carried mobile phones that noted visit time, length, content covered, and perceived impact.
On average, CHWs made six antenatal visits (range, 1–27) and five postnatal visits between birth and 2 months postbirth (range, 1–12) per participant. Sessions averaged 31 min (SD = 20). Supervisors monitored implementation by reviewing charts and visit documentation on mobile phones, making random site visits once every 2 weeks, and providing monthly CHW in-service trainings.
Neighborhood matching and randomization
Household randomization would have increased the intervention's stigma and resulted in substantial contamination; therefore, we randomized by neighborhood. Similar neighborhoods (N = 40) were selected based on analysis of aerial photos, field observations, brief street-intercept surveys, and systematic counting of the number of alcohol bars, informal shops, clinics, child care centers, schools, and formal and informal houses per neighborhood. On the basis of these data, we identified 13 matched pairs of similarly-sized neighborhoods (450–600 households) with formal and informal housing, that were within 5 km of health clinics; had five to seven alcohol bars; were noncontiguous or separated by natural barriers; had similar numbers of child care centers, informal shops, and schools; and had households with similar length of residence. In a cluster randomized controlled design, the UCLA team randomized neighborhoods within matched pairs to PIP or standard care using simple randomization. One matched pair was eliminated after 6 months of recruitment due to low numbers of pregnant women (total n = 10 pregnant women), leaving 24 study neighborhoods .
Sample size calculations
Sample size calculations were conducted to determine the minimum number of pregnant women to be recruited per neighborhood to achieve 80% power to detect a standardized effect size of 0.40 between intervention conditions among WLH and among all women .
Recruitment and retention
Three separate teams conducted the study to reduce any potential bias in data collection (Stellenbosch), intervention implementation (the Philani Program), and analyses (UCLA). From May 2009 to September 2010, the Stellenbosch team hired local township mothers to recruit pregnant women who were at least 18 years old, living within the target neighborhood, and able to give informed consent. Each recruiter worked in one PIP and one standard care neighborhood to ensure that recruiter competence was similar across conditions. Pregnant women were recruited at an average 26 weeks of pregnancy (range, 3–40 weeks); only 2% of women refused participation. Initially, however, we identified 22% fewer pregnant women in standard care. By redeploying recruiters, we identified an additional 94 women in 10 of the 12 standard care neighborhoods who were pregnant during the recruitment period (median of seven late-entry participants per neighborhood; range, 3–24). These women were enrolled postbirth when their infants were a mean age of 9 months old (range, 1–18 months). The final sample (n = 1238) consisted of a median of 51 pregnant women per neighborhood (range, 23–72).
Figure 1 summarizes participant flow from recruitment to 6 months postbirth. Follow-up rates were similar across intervention conditions: 92% were reassessed postbirth (Mean = 1.9 weeks; SD = 2.1), 88% at 6 months (Mean = 6.2 months, SD = 0.7), and 88% were assessed at all three points. Due to delayed enrollment, late-entry participants were asked baseline, postbirth, and 6-month questions in one assessment.
Township women were trained as interviewers, used mobile phones for data entry, and were routinely monitored and supervised. A driver transported all participants to a central assessment site, allowing interviewers to be blinded to condition. However, participants may have spontaneously talked about CHWs to interviewers.
HIV-related preventive acts
HIV-related preventive acts (self-reported) included asking partners to test for HIV; discussing HIV status with sexual partners in the past 3 months; and using condoms consistently (in 10 of the last 10 sexual episodes). All pregnant women reported whether they completed the rapid HIV test in the antenatal clinic, received their results, and completed a blood test to evaluate CD4 cell count. Among WLH, there were additional perinatal tasks that included knowledge of CD4 cell count and behaviors in the PMTCT cascade [18,19]: adherence to ZDV from the 28th week of pregnancy; ZDV during labor; NVP during labor; infant NVP postbirth; infant ZDV postbirth; infant HIV PCR testing at 6 weeks and retrieval of results; and maintenance of one feeding method (either breastfeeding or formula) for 6 months. We calculated the percentage of women completing each task and the percentage of women who cumulatively completed steps in the PMTCT cascade.
Child health and nutrition
Child health and nutrition was assessed by low birth weight (LBW, <2500 g) and by calculating z-scores based on WHO age-specific and sex-specific standards for weight, height/length, weight-for-height, and head circumference . A z-score below −2 standard deviations was considered a serious growth deficit . We monitored self-reports of months of breastfeeding (then dichotomized as longer than the sample median of 3 months), breastfeeding exclusively for 6 months, alcohol use the month before birth, and risky drinking postbirth, assessed by the Alcohol Use Disorders Identification Test-C (AUDIT-C) .
Healthcare was tracked by maternal reports of antenatal clinic visits, postbirth complications (heavy vaginal bleeding, malodorous discharge, fever, persistent cough, breast infection), and TB testing. The infant's Road-to-Health card reported immunizations, clinic visits, and results of HIV PCR testing and formula feeding (allowing us to validate maternal self-reports of HIV status).
Mental health was measured by the Edinburgh Postnatal Depression Scale (EPDS), using a cut-off of more than 13 to indicate depressed mood [23,24].
Social support was assessed by the frequency of material, emotional, and child-rearing support from family members, neighbors, and friends, and whether mothers applied for and received the child grant (R240/month, about 30 USD).
Among WLH and among all mothers, we first looked for significant differences in baseline demographics between intervention conditions and between participants lost to follow-up vs. those reassessed at postbirth and 6 months. For WLH and for all mothers, our primary analysis of the impact of the intervention at 6 months compared women in PIP and standard care using a binomial test of the number of significant effects favoring PIP among our 28 measures. Our secondary analyses explored differences in individual outcomes between conditions among WLH and among all participants.
Primary analysis: binomial test for correlated outcomes
Comparisons between PIP and standard care on 28 binary outcomes were tested at a one-sided upper-tail α equal to 0.025 using logistic random effects regressions adjusting for neighborhood clustering in SAS PROC GENMOD (version 9.2; SAS Institute Inc., Cary, North Carolina, USA). All models included an indicator variable for intervention status (1 = PIP, 0 = standard care). Among WLH, we controlled for baseline employment because it differed significantly between intervention conditions; among all participants, there were no significant baseline differences between conditions.
We can expect 28 × 0.025 = 0.7 significant tests (i.e. less than 1 of 28) on average if there are no differences between PIP and standard care. If outcomes are independent, the probability that there are three or fewer significant differences is 99.5%, leading to a type 1 error of 0.005. However, the outcomes are likely positively correlated, which does not affect the expected number of positive tests, but does affect the variance of the number of positive tests. To study the effects of global positive correlation among all outcomes on the number of positive tests assuming no intervention effect, we treated each of our 28 tests as a normal z-test (z-statistics were assumed to come from an equicorrelated multivariate normal distribution) and simulated 40 000 trials of the number of significant outcomes, for z-tests having mutual correlations ρ for ρ running from 0 to 0.9 in steps of 0.1. We declared significance for z more than 1.96. Simulations were performed in R (version 2.11.1).
Across the 10 correlations, using a decision rule of rejecting the null of no PIP treatment effect given four or more significant tests of 28, the worst situation was that we reject the null with probability 0.059 when ρ = 0.7. For more reasonable correlations of ρ equal to 0.1 or 0.2, the actual type 1 error is 0.021 and 0.037, respectively. We estimated the average absolute correlations among the outcomes; because variables included ‘true dichotomies’ (e.g. Asked partner to test for HIV) and indicators created by dichotomizing continuous outcomes (e.g. Weight-for-age z-score ≥ −2), we estimated both the Pearson and the tetrachoric correlations, planning to use whichever method produced higher average absolute correlations. If the correlations were found to be higher than 0.2, we would increase the needed number of significant results from four to five of 28 before declaring PIP's significance. This would keep the type 1 error below 0.05, no matter what the outcomes’ correlations.
As we performed two binomial tests, one for WLH and one for all women, we examined the P values to see whether each was below 0.05/2 = 0.025 to control for the family-wise error rate before declaring a significant result in favor of PIP.
We tested PIP's impact on individual outcomes at a two-sided α equal to 0.05 using the regressions described above. We used the same models to estimate PIP's effect on completing all tasks in the PMTCT cascade. We considered our secondary analyses to be exploratory and retained the model P values in lieu of a multiple-testing adjustment.
Late-entry participants with infants in the same age range as regular-entry participants’ infants at a particular assessment were included in analyses, when possible. Overall, results were similar whether or not late-entry participants’ data were included; results are available upon request.
Baseline characteristics of overall sample
Table 1 summarizes the self-reports of PIP and standard care mothers at baseline. Women were similar across conditions on outcome-related measures, such as HIV testing, receiving HIV test results, asking partners to test, knowledge of partner HIV status, alcohol use in pregnancy, rates of prior LBW infants, depression, and social support measures; matching criteria, such as housing type, water source, and presence of flush toilet and electricity on premises; demographic characteristics, including age, marital status, education, employment status, and household income; and general health, including HIV and TB infection rates. One significant baseline difference between PIP and standard care was noted: among women who had been pregnant before, standard care had a higher mean number of previous births. There were no significant selection effects between mothers who were successfully reassessed over the 6 months postbirth and those who were not. There were no serious study-related adverse events. Over 6 months, less than 1% of mothers died, and about 8% of infants died, similar across conditions.
Postbirth and 6-month outcome measures
Women living with HIV
At the baseline interview, 295 women reported an HIV-positive serostatus. Between the baseline and 6-month assessments, 59 additional women disclosed an HIV-positive serostatus to the researchers (n = 354, 29%). About 20% of WLH were prescribed lifelong antiretroviral drugs. At 6 months, 2% of WLH's infants were HIV-positive.
The average absolute correlation between the 28 measures using the Pearson and the tetrachoric correlations was 0.088 and 0.202, respectively. As shown in Table 2, PIP outperformed standard care on six of 28 outcomes, resulting in PIP having significantly better overall maternal and infant well being over the first 6 months postbirth compared to standard care using the binomial test (correlation = 0.2, P = 0.009).
On specific PMTCT tasks (Table 2), WLH were similar across conditions in the percentage of WLH adhering to antiretrovirals surrounding childbirth and seeking infant PCR testing. PIP WLH were more likely to administer infant NVP at birth (odds ratio, OR = 2.94; two-sided P = 0.004), correctly medicate infants with ZDV (OR = 2.95; P = 0.028), and practise one feeding method for the first 6 months (OR = 1.81; P = 0.002). Cumulative completion of the tasks in the PMTCT cascade (Fig. 2) was greater in PIP compared to standard care (OR = 1.95; P < 0.001). Furthermore, compared to standard care, PIP WLH were more likely to have infant height-for-age z-score at least −2 (OR = 1.63; P = 0.013), be free of postbirth complications (OR = 2.26; P = 0.002), and have the father acknowledge the infant to his family (OR = 4.66, P = 0.007). However, PIP WLH were less likely than standard care WLH to know their CD4 cell count (OR = 0.51, P = 0.017).
The average absolute correlation between the 28 measures among the full sample using the Pearson and the tetrachoric correlations was 0.075 and 0.173, respectively. As shown in Table 3, PIP outperformed standard care on seven of 28 outcomes; thus, using the binomial test, we can declare PIP to have resulted in significantly better overall maternal and infant well being over the first 6 months postbirth compared to standard care (correlation = 0.2, P = 0.005).
PIP and standard care mothers and infants differed significantly on individual outcomes. HIV prevention differed by condition: consistent condom use was higher in PIP compared to standard care (OR = 1.52; two-sided P = 0.002), and, as described previously, there were significant differences in adherence to PMTCT tasks. Furthermore, PIP infants were more likely to have height-for-age z-score at least −2 (OR = 1.69; P = 0.002), breastfeed longer than the median number of 3 months (OR = 3.08; P < 0.001), and breastfeed exclusively for 6 months postbirth (OR = 3.59; P < 0.001). Healthcare, maternal depression, social support, and the percentage of mothers securing the child grant were similar across conditions.
This study demonstrates the effectiveness of a CHW model for delivering home-based preventive care by addressing multiple health issues. We focused on the issues most salient in pregnancy in South Africa: HIV, alcohol use, and perinatal care. These were concurrently addressed with a model of pragmatic problem-solving with cognitive-behavioral intervention strategies. The South African government has begun to implement a similar model through a process they have termed ‘re-engineering primary healthcare’  and plans to deploy about 65 000 CHWs. We found significant benefits in overall maternal and infant well being for WLH and all neighborhood women and demonstrated the specific domains of improvement, especially for WLH. This model may be useful for countries that aim to promote task-shifting from professionals to CHWs in order to achieve HIV reduction and their Millennium Development Goals .
The gains for WLH and their children were broader than only adhering to PMTCT tasks. WLH and their children face life-long challenges, and home visits by CHWs create a vehicle for providing ongoing support to WLH and all community women. By having CHWs identified with a maternal, child health and nutrition program, much of the stigma associated with HIV is side-stepped. By focusing training on generic, common principles of behavior change and the specific health challenges of the local community, the potential exists to broadly diffuse the training model [26,27], allowing tailoring to the prevailing local diseases. Consistent with previous recommendations , the implementation was mounted by an agency with strong ties to community leaders, stakeholders, and clinical care sites; by CHWs who received a stipend to sustain the program; and following stringent supervision standards.
All neighborhoods (PIP and standard care) had nearby access to clinic and hospital services, which provided access to dual antiretroviral regimens for PMTCT. In the Cape Town area, PMTCT adherence rates are higher than in many parts of South Africa. In fact, the PMTCT adherence rates of WLH in standard care exceeded those observed in other studies of pregnant women in South Africa . Yet, the odds of completing all PMTCT tasks were 1.95 times higher in PIP than standard care.
The gains from our study are significant, but modest. However, small gains often become magnified over time. Pregnancy and infancy are critical developmental phases with lifelong consequences; small changes that become habits can have substantial impact over a lifetime [10,30]. As our trial's primary endpoint is 18 months, we are continuing to monitor outcomes and will report final results when the trial is complete.
A universal goal in crafting interventions is sustainability. CHWs visited families on average six times during pregnancy and five times between birth and 2 months postbirth. This is substantially more intensive than most vertical, single-disease-targeted interventions that have been implemented in South Africa and globally. However, PIP has been ongoing since the 1990s and CHWs’ salaries and experience are in line with South African government guidelines [31,32] and would, therefore, be sustainable. In addition to sustainability, home visits offer a viable strategy to circumvent challenges associated with obtaining healthcare from clinics. Clinic appointments are difficult to schedule; waiting lines are long; transport is expensive; and mothers must coordinate their own and infants’ care across multiple clinics [32,33]. A CHW approach grounded in cognitive-behavioral skills, with locally tailored content addressing local health risks, may be a strategy that is scalable globally.
A noteworthy innovation was the use of mobile phones for data collection, and monitoring and supporting CHW . Supervision and field support have often been major barriers to consistent, sustained CHW performance . Mobile phones provided a tool for routine feedback in our study, and proved to be an effective supervisory tool, especially when combined with in-person supervision.
More than 1 million additional professional healthcare workers are required to meet existing health demands . Task-shifting from healthcare professionals to CHWs has the potential to address this need . PIP provided both task-shifting and site-shifting (from clinics to communities). It allows governments to leverage the investments in HIV to address concurrent health issues. PIP offers an intervention model and evaluation strategy for building sustainable, locally tailored CHW home visiting programs.
I.M.le R., M.T., R.E.W., and M.J.R.-B. conceived the study, planned the study design, and led preparation of the article. R.E.W. designed the data analyses and J.M.H. conducted the data analyses and authored sections of the article. M.J.O’C., R.E.W., C.M.W., D.S., and W.S.C. consulted on study design, measure selection, data analyses, and edited and commented on the article. N.M., J.S., and M.H. led study implementation, authored sections, and commented on the article.
This study was funded by NIAAA Grant # 1R01AA017104 and supported by NIH grants MH58107, 5P30AI028697, and UL1TR000124. M.T. is supported by the National Research Foundation (South Africa).
The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the article.
The corresponding author has the right to grant on behalf of all authors and does grant on behalf of all authors, a worldwide licence to the Publishers and its licensees in perpetuity, in all forms, formats, and media (whether known now or created in the future), to publish, reproduce, distribute, display, and store the Contribution; translate the Contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the Contribution; create any other derivative work(s) based on the Contribution; to exploit all subsidiary rights in the Contribution; include electronic links from the Contribution in third party material wherever it may be located; and, licence any third party to do any or all of the above.
Trial Registration: ClinicalTrials.gov registration # NCT00996528.
Conflicts of interest
No authors have any competing interests. All authors have completed the Authorship Responsibility, Financial Disclosure, and Copyright Transfer form and declare no conflicts of interest: no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years, no other relationships or activities that could appear to have influenced the submitted work.
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