Missed opportunities for HIV testing and counselling in Asia
Sullivan, Sheena Ga,b; Wu, Zunyoua,b; Detels, Rogera
aDepartment of Epidemiology, University of California, Los Angeles, USA
bNational Centre for AIDS/STD Control and Prevention, Beijing, PR China.
Correspondence to Professor Roger Detels, Department of Epidemiology, University of California, Los Angeles, Box 951772, Los Angeles, CA 90095-1772, USA. Tel: +1 310 206 2837; fax: +1 310 206 6039; e-mail: firstname.lastname@example.org
The US Centers for Disease Control and Prevention recently estimated that persons living with HIV/AIDS (PLHA) in the United States unaware of their serostatus may account for 54–70% of new infections . Increasing awareness from the current 75 to 100% could reduce sexual transmission by 40% . In Asia, where fewer than half of PLHA are aware of their serostatus (see Table 1) [3–17], the contribution to the epidemic made by people unaware of their serostatus is likely to be much higher. Thus, testing is a key component of HIV prevention strategies. This paper reviews the current situation and discusses strategies to increase HIV testing in Asia.
The need for testing in HIV prevention and control
Irrespective of the result, testing provides an important opportunity to counsel clients on ways to increase their protective behaviours; many of those who test positive will subsequently reduce their risk behaviours [18,19]. Counselling also provides a gateway to accessing antiretroviral treatment and care, which reduces viral load and, therefore, the infectivity of treated PLHA – theoretically, universal treatment could eliminate HIV . Moreover, treatment extends the lives of AIDS patients and reduces AIDS mortality.
Table 1 shows the number of reported HIV infections versus the estimated total infections for several Asian countries. The large differences in these numbers suggests that most PLHA are unaware of their serostatus. Many of those testing positive are presenting with AIDS; in China, 66% of new AIDS cases in 2009 were newly identified infections (National Center for AIDS/STD Control and Prevention, unpublished study) and in Japan, roughly, 30% of those testing positive for the first time had AIDS . This trend is worrying because late presenters have a worse prognosis  and may have inadvertently exposed their contacts for more than 8 years .
Barriers to HIV testing in Asia
Many Asian countries simply lack the infrastructure to support wide-scale testing of their populations, including convenient testing facilities, competent laboratories, and staff. Governments necessarily locate clinics in areas of greatest need, leaving some low prevalence areas without services. Establishing these facilities can consume much of the total HIV budget; for example, 20% of Thailand's 2007 AIDS budget was spent on voluntary counselling and testing (VCT) . Moreover, governments need to factor in the costs of providing antiretroviral drugs to discovered AIDS patients. For clients, the costs of testing may be prohibitive – ostensibly-free tests may in practice come with service fees and the time and costs of getting to clinics and the consequent loss of pay may be unaffordable . Travel subsidies could alleviate this problem, as has worked for antiretroviral therapy (ART) programmes in India .
Without adequately informed campaigns, people may simply be unaware of testing locations or their personal risk . Even highly targeted campaigns may fail. For example, some of the AIDS patients testing for the first time in China last year were former plasma donors from provinces that have experienced years of testing campaigns, have ample facilities to provide testing, and have already tested thousands among this group .
Stigma and discrimination may have deterred many former plasma donors from seeking earlier testing . Fearing a positive test result could lead to lost employment, education, and other social services as well as neglect, abandonment, or abuse . Many are reluctant to visit testing clinics [27,29]. For cost-effectiveness, HIV prevention programmes are primarily targeted at high-risk groups (Table 2) [3–5,8–14,24,31–36], but enhanced stigma towards these groups may contribute to low testing and low rates of return. Health systems may inherently discriminate; for example, sex workers in Thailand seeking health services are given differently coloured outpatient cards from those given to other types of patients, which could discourage them from seeking testing . Healthcare workers may have negative attitudes, which can deter them from working in the field  (further exacerbating human resource limitations) and influences the quality of their services, particularly counselling [37–40]. Poor pretest counselling can disincline patients from accepting testing and may contribute to low rates of return for results . Even when clients do return, results may be received in silence (for example, Vietnam , China ), without any posttest counselling, which is extremely important for connecting clients with treatment, support, and prevention services and has been associated with greater reductions in subsequent risk behaviours [42,43]. Although countries ostensibly agree to uphold the World Health Organization (WHO) standards for testing and counselling , noncompliance, especially disrespect for patient confidentiality, happens (for example, India ). Several countries, including Bangladesh , Cambodia , China , and the Philippines , have introduced legislation or policies to protect the rights of people living with HIV/AIDS (PLHA) and require healthcare staff to maintain confidentiality. Governments should hold their hospitals, clinics, and healthcare staff accountable to such regulations.
HIV testing strategies
The traditional approach to testing – which requires clients to request testing – has failed to adequately identify the majority of PLHA. Thus, strategies that relieve clients of the burden of initiating awkward conversations with often judgemental healthcare providers are needed.
Recently, UNAIDS/WHO have promoted provider-initiated testing and counselling (PITC) to avoid missed opportunities for testing . In PITC, clients with signs, symptoms, or risk behaviours are recommended for testing by their healthcare providers, who will carry out the test unless the patient declines. For the low-level-to-concentrated epidemic in Asia, PITC is recommended for sexually transmitted infection (STI) clinics, clinics for other at-risk populations, antenatal clinics, and tuberculosis services. Many countries have begun implementing PITC (for example, India , Mongolia , Nepal , Singapore , Malaysia ), with promising results; for example, PITC among Vietnamese tuberculosis patients more than doubled the number of patients known to be HIV-positive .
Routine testing is also practised, typically for drug users sent for detoxification or entering methadone programmes (for example, China ), and sex workers sent to re-education/labour camps (for example, China , Vietnam ). Routine testing in principle follows the opt-out model used in PITC, but in practice may border on mandatory testing as those tested may not know what the test is for or that they can refuse, and results may not be communicated well, if at all. Mandatory testing is not recommended because it typically includes no counselling and may be insufficiently linked with support and preventive services. However, some countries require it for military recruits (for example, Indonesia , Malaysia , Thailand ; troops sent on UN peacekeeping missions) and foreigners on a work visa (for example, Malaysia , Maldives ).
Routine testing or referral of partners of PLHA is practised in some countries (for example, Malaysia , the Philippines ), but adoption has been slow . For example, a decade ago in Japan, routine partner screening was recommended as a cost-effective control strategy , yet it still is not standard practice. The strategy is controversial because while it recognizes a person's right to know their risks, disclosure can be risky for some . However, one review suggested that partner notification could increase HIV testing among high-risk individuals and identified no significant harms .
Of course, no test is useful if clients do not return for their results, and the low frequency of return is a significant problem in Asia. The data in Tables 1 and 2 do not distinguish between total numbers tested and the numbers who received their result and these discrepancies may be large. Rapid tests can increase the proportion of those tested who know their result . They are faster, less invasive, easier for healthcare workers to use, and alleviate the need for sophisticated laboratory support, making them suitable for rural and remote areas [64,65]. Although more expensive than the traditional ELISA, rapid tests may be more cost-effective if return rates are factored in. Rapid testing has been introduced in several Asian countries, including Bangladesh , Cambodia , and Singapore , though it is not necessarily free. Home self-testing could also increase awareness but poses several risks (discussed in [25,68–70]) and to our knowledge has not been endorsed by any of Asia's governments.
HIV testing and counselling is not by itself able to control the HIV epidemic. However, as stated by UNAIDS ‘Among the interventions which play a pivotal role both in treatment and in prevention, HIV testing and counselling stands out as paramount’ . Asian governments are expanding the availability of testing services. Their utilization could be increased if PITC, partner referral, and rapid testing were the norm and were free. Governments should ensure through policy that these services are delivered with respect, confidentiality, and counselling that puts clients in contact with prevention, treatment, and care services. Although governments can introduce legislation to protect the rights of PLHA, shifting the attitudes of the populace to eliminate stigma and the fear of a positive test result will be far harder and slower to achieve than structural or policy changes. However, efforts to make testing and counselling available and accessible should continue so that a majority of PLHA can learn about and manage their disease and protect their partners and so that those putting themselves at risk can have access to prevention services. Without greater awareness, it will be difficult to control this epidemic.
The authors would like to thank Drs Thuong Nguyen, Panithee Thammawijaya, and Chhea Chhorvann for providing information on testing procedures in their countries. Sheena Sullivan is partially supported by a Lionel Murphy Foundation Scholarship.
Conflicts of interest: None.
1. Marks G, Crepaz N, Janssen RS. Estimating sexual transmission of HIV from persons aware and unaware that they are infected with the virus in the USA. AIDS 2006; 20:1447–1450.
2. Holtgrave DR, Pinkerton SD. Can increasing awareness of HIV seropositivity reduce infections by 50% in the United States? J Acquir Immune Defic Syndr 2007; 44:360–363.
18. Wolitski RJ, MacGowan RJ, Higgins DL, Jorgensen CM. The effects of HIV counseling and testing on risk-related practices and help-seeking behavior. AIDS Educ Prev 1997; 9:52–67.
19. Marks G, Crepaz N, Senterfitt JW, Janssen RS. Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States: implications for HIV prevention programs. J Acquir Immune Defic Syndr 2005; 39:446–453.
20. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 2009; 373:48–57.
22. Girardi E, Sabin CA, Monforte AD. Late diagnosis of HIV infection: epidemiological features, consequences and strategies to encourage earlier testing. J Acquir Immune Defic Syndr 2007; 46(Suppl 1):S3–S8.
23. Alcabes P, Munoz A, Vlahov D, Friedland GH. Incubation period of human immunodeficiency virus. Epidemiol Rev 1993; 15:303–318.
25. Kachroo S. Promoting self-testing for HIV in developing countries: potential benefits and pitfalls. Bull World Health Organ 2006; 84:999–1000.
26. Rewari B. Scaling-up access to paediatric ART in India. International AIDS Conference. Mexico City; 3–8 August 2008.
27. Ma W, Detels R, Feng Y, Wu Z, Shen L, Li Y, et al
. Acceptance of and barriers to voluntary HIV counselling and testing among adults in Guizhou province, China. AIDS 2007; 21(Suppl 8):S129–S135.
28. Wu Z, Sun X, Sullivan SG, Detels R. Public health. HIV testing in China. Science 2006; 312:1475–1476.
29. Maher L, Coupland H, Musson R. Scaling up HIV treatment, care and support for injecting drug users in Vietnam. Int J Drug Policy 2007; 18:296–305.
30. Busza JR. Promoting the positive: responses to stigma and discrimination in southeast Asia. AIDS Care 2001; 13:441–456.
37. Li L, Lin C, Wu Z, Wu S, Rotheram-Borus MJ, Detels R, Jia M. Stigmatization and shame: consequences of caring for HIV/AIDS patients in China. AIDS Care 2007; 19:258–263.
38. Hesketh T, Duo L, Li H, Tomkins AM. Attitudes to HIV and HIV testing in high prevalence areas of China: informing the introduction of voluntary counselling and testing programmes. Sex Transm Infect 2005; 81:108–112.
39. Ngo AD, Ratliff EA, McCurdy SA, Ross MW, Markham C, Pham HT. Health-seeking behaviour for sexually transmitted infections and HIV testing among female sex workers in Vietnam. AIDS Care 2007; 19:878–887.
40. Ford K, Wirawan DN, Sumantera GM, Sawitri AA, Stahre M. Voluntary HIV testing, disclosure, and stigma among injection drug users in Bali, Indonesia. AIDS Educ Prev 2004; 16:487–498.
41. Bergenstrom A, Go V, Nam LV, Thuy BT, Celentano DD, Frangakis C, Quan VM. Return to posttest counselling by out-of-treatment injecting drug users participating in a cross-sectional survey in north Vietnam. AIDS Care 2007; 19:935–939.
42. Kamb ML, Fishbein M, Douglas JM Jr, Rhodes F, Rogers J, Bolan G, et al
. Efficacy of risk-reduction counseling to prevent human immunodeficiency virus and sexually transmitted diseases: a randomized controlled trial. Project RESPECT Study Group. JAMA 1998; 280:1161–1167.
43. The Voluntary HIV-1 Counseling and Testing Efficacy Study Group. Efficacy of voluntary HIV-1 counselling and testing in individuals and couples in Kenya, Tanzania, and Trinidad: a randomised trial
45. Datye V, Kielmann K, Sheikh K, Deshmukh D, Deshpande S, Porter J, Rangan S. Private practitioners' communications with patients around HIV testing in Pune, India. Health Policy Plan 2006; 21:343–352.
46. National Policy on HIV/AIDS and STD related issues. Directorate General of Health Services, Ministry of Health and Family Welfare, Government of The People's Republic of Bangladesh; 1995.
48. State Council of P.R. China. Regulations on AIDS prevention and treatment. Beijing; 2006.
50. WHO, UNAIDS. Guidance on provider-initiated HIV testing and counselling in health facilities. Geneva: World Health Organization; 2007.
56. Nhung N, Thai L, TT T, Tung V, Whitehead S, Wolfe M, Varma J. Expansion of provider-initiated HIV testing and counseling for TB patients to 14 provinces in Vietnam, 2007–2008
. 9th International Congress on AIDS in Asia and the Pacific. Bali; 9–13 August 2009.
57. National AIDS Commission. Country report on the follow up to the Declaration of Commitment on HIV/AIDS. Jakarta: National AIDS Commission, Republic of Indonesia; 2008.
59. Dixon-Mueller R. The sexual ethics of HIV testing and the rights and responsibilities of partners. Stud Fam Plann 2007; 38:284–296.
60. Rahman M, Fukui T, Asai A. Cost-effectiveness analysis of partner notification program for human immunodeficiency virus infection in Japan. J Epidemiol 1998; 8:123–128.
61. Yeatman SE. Ethical and public health considerations in HIV counseling and testing: policy implications. Stud Fam Plann 2007; 38:271–278.
62. Hogben M, McNally T, McPheeters M, Hutchinson AB. The effectiveness of HIV partner counseling and referral services in increasing identification of HIV-positive individuals: a systematic review. Am J Prev Med 2007; 33:S89–S100.
63. Hutchinson AB, Branson BM, Kim A, Farnham PG. A meta-analysis of the effectiveness of alternative HIV counseling and testing methods to increase knowledge of HIV status. AIDS 2006; 20:1597–1604.
64. Farnham PG, Hutchinson AB, Sansom SL, Branson BM. Comparing the costs of HIV screening strategies and technologies in health-care settings. Public Health Rep 2008; 123(Suppl 3):51–62.
65. Ekwueme DU, Pinkerton SD, Holtgrave DR, Branson BM. Cost comparison of three HIV counseling and testing technologies. Am J Prev Med 2003; 25:112–121.
67. NCHADS. Voluntary Confidential Counseling and Testing (VCCT). Phnom Penh: National Center for HIV/AIDS Dermatology and STD; 2005.
68. Frerichs RR. Personal screening for HIV in developing countries. Lancet 1994; 343:960–962.
69. Frith L. HIV self-testing: a time to revise current policy. Lancet 2007; 369:243–245.
70. Spielberg F, Levine RO, Weaver M. Self-testing for HIV: a new option for HIV prevention? Lancet Infect Dis 2004; 4:640–646.
© 2010 Lippincott Williams & Wilkins, Inc.
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