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AIDS:
doi: 10.1097/QAD.0b013e32832cbd59
Correspondance

Response to Castelnuovo et al. regarding our article ‘Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda’

Reynolds, Steven Ja,b; Quinn, Thomas Ca,b; Gray, Ronald Hc; Serwadda, Davidd

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Author Information

aDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

bJohns Hopkins University School of Medicine, USA

cJohns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

dMakerere University School of Public Health, Kampala, Uganda.

Received 9 April, 2009

Accepted 9 April, 2009

The data of Castelnuovo et al. from an urban HIV clinic in Kampala confirm our report and other reports by colleagues in eastern Uganda that the current WHO monitoring guidelines are suboptimal [1–3]. The consistency of the findings underscores the importance of ongoing revision of current antiretroviral treatment monitoring guidelines with consideration of viral load testing to identify individuals failing therapy.

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References

1. Reynolds S, Nakigozi G, Newell K, Ndyanabo A, Galiwongo R, Boaz I, et al. Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda. AIDS 2009; 23.

2. Castelnuovo B, Kiragga A, Schaefer P, Kambugu A, Manabe Y. High rate of misclassification of treatment failure based on WHO immunological criteria. AIDS 2009; 23.

3. Moore DM, Mermin J, Awor A, Yip B, Hogg RS, Montaner JS. Performance of immunologic responses in predicting viral load suppression: implications for monitoring patients in resource-limited settings. J Acquir Immune Defic Syndr 2006; 43:436–439.

© 2009 Lippincott Williams & Wilkins, Inc.

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